RECRUITING

Improving Implementation of Evidence-based Approaches and Surveillance to Prevent Bacterial Transmission and Infection

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Surgical site infections (SSIs) are associated with increased patient morbidity, mortality, and healthcare costs. ESKAPE (Enterococcus, S. aureus, Klebsiella, Acinetobacter, Pseudomonas, and Enterobacter spp.) pathogens are particularly pathogenic because they have increased capacity to acquire resistance and virulence traits. The investigators have proven that a multifaceted program involving improved basic perioperative preventive measures can generate substantial reductions in S. aureus transmission and significant reductions in SSIs (88% reduction as compared to usual care). In this study, the investigators aim to examine the relative effectiveness of each component of this program in controlling ESKAPE transmission and reducing SSIs and to identify an optimal implementation strategy for national dissemination. Randomization occurs at the site level, and sites adopt preventative programs. This work will improve perioperative patient safety for the 51 million patients who undergo surgery each year.

Official Title

The BASIC Trial: Improving Implementation of Evidence-based Approaches and Surveillance to Prevent Bacterial Transmission and Infection

Quick Facts

Study Start:2021-07-01
Study Completion:2026-06-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04600973

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * operating room conducting orthopedic total joint and spine
  2. * Surgeons performing orthopedic total joint or spine
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Contact

Jeremiah R Brown, PhD
CONTACT
603-646-5409
jbrown@dartmouth.edu
Iben Sullivan, PhD
CONTACT
Iben.K.Sullivan@dartmouth.edu

Principal Investigator

Jeremiah R Brown, PhD
PRINCIPAL_INVESTIGATOR
Trustees of Dartmouth College
Randy Loftus, MD
PRINCIPAL_INVESTIGATOR
Mayo Clinic
Ib en K Sullivan, PhD
STUDY_DIRECTOR
Trustees of Dartmouth College

Study Locations (Sites)

Mayo Clinic
Rochester, Minnesota, 55905
United States
Trustees of Dartmouth College
Hanover, New Hampshire, 03755
United States

Collaborators and Investigators

Sponsor: Trustees of Dartmouth College

  • Jeremiah R Brown, PhD, PRINCIPAL_INVESTIGATOR, Trustees of Dartmouth College
  • Randy Loftus, MD, PRINCIPAL_INVESTIGATOR, Mayo Clinic
  • Ib en K Sullivan, PhD, STUDY_DIRECTOR, Trustees of Dartmouth College

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-07-01
Study Completion Date2026-06-30

Study Record Updates

Study Start Date2021-07-01
Study Completion Date2026-06-30

Terms related to this study

Keywords Provided by Researchers

  • transmission
  • ESKAPE
  • prevention

Additional Relevant MeSH Terms

  • Infection