Role of Nutrient Transit in Hyperinsulinemic Hypoglycemia

Description

Severe hypoglycemia (low blood sugar)after gastric bypass surgery is an increasingly recognized condition, characterized by symptoms of hypoglycemia after eating and inappropriately elevated insulin concentrations that occur at the time of hypoglycemia. Severe hypoglycemia can be dangerous and debilitating and can also impact cognitive function. At the moment no medical therapies have been developed for this disorder. Determining why some but not other patients develop this condition would allow for improved prediction, prevention, and treatment approaches. The purpose of the study is to understand the physiological changes observed in those patients who undergo gastric bypass and develop symptomatic hypoglycemia.

Conditions

Post-Bariatric Hypoglycemia

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Study Overview

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Study Details

Study overview

Severe hypoglycemia (low blood sugar)after gastric bypass surgery is an increasingly recognized condition, characterized by symptoms of hypoglycemia after eating and inappropriately elevated insulin concentrations that occur at the time of hypoglycemia. Severe hypoglycemia can be dangerous and debilitating and can also impact cognitive function. At the moment no medical therapies have been developed for this disorder. Determining why some but not other patients develop this condition would allow for improved prediction, prevention, and treatment approaches. The purpose of the study is to understand the physiological changes observed in those patients who undergo gastric bypass and develop symptomatic hypoglycemia.

Role of Nutrient Transit and Incretin Hormones in Hyperinsulinemic Hypoglycemia

Role of Nutrient Transit in Hyperinsulinemic Hypoglycemia

Condition
Post-Bariatric Hypoglycemia
Intervention / Treatment

-

Contacts and Locations

Stanford

Stanford University School of Medicine, Stanford, California, United States, 94305-5103

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Male or female patients 18-70 years of age
  • * Post-bariatric surgery more than 6 months prior to signing the informed consent (not required for non-surgical controls)
  • * Documented history of hyperinsulinemic hypoglycemia (not required for post-bariatric and non-surgical controls)
  • * Patients currently using sulfonylureas or other medications that may interfere with glucose metabolism within 5 half-lives of drug.
  • * Participation in any clinical investigation within 4 weeks prior to dosing
  • * History of or current insulinoma
  • * Active infection or significant acute illness within 2 weeks prior to dosing
  • * Female patients who are pregnant or lactating
  • * Women of childbearing potential and not utilizing effective contraceptive methods
  • * Inadequate end organ function as defined by: Serum creatinine \>2.0 mg/dL, alanine transaminase (ALT) and aspartate aminotransferase (AST) \> 2 x Upper Normal Limit
  • * Allergy to test meal or medications used in the study

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Stanford University,

Tracey McLaughlin, MD, PRINCIPAL_INVESTIGATOR, Stanford University

Colleen Craig, MD, STUDY_DIRECTOR, Stanford University

Study Record Dates

2026-06