IPT for Major Depression Following Perinatal Loss: Healing After Loss (HeAL)

Description

This study tests the efficacy of interpersonal psychotherapy (IPT) for major depression following perinatal loss (early and late fetal death and early neonatal death) in a sample of 274 women in Flint and Detroit, Michigan. The trial will be the first fully powered randomized trial of treatment for any psychiatric disorder following perinatal loss.

Conditions

Major Depressive Disorder

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Study Overview

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Study Details

Study overview

This study tests the efficacy of interpersonal psychotherapy (IPT) for major depression following perinatal loss (early and late fetal death and early neonatal death) in a sample of 274 women in Flint and Detroit, Michigan. The trial will be the first fully powered randomized trial of treatment for any psychiatric disorder following perinatal loss.

IPT for Major Depression Following Perinatal Loss: Healing After Loss (HeAL)

IPT for Major Depression Following Perinatal Loss: Healing After Loss (HeAL)

Condition
Major Depressive Disorder
Intervention / Treatment

-

Contacts and Locations

Flint

Anywhere in the entire state of Michigan (treatment is virtual), Flint, Michigan, United States, 48502

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * women who meet current Diagnostic and Statistical Manual 5 (DSM-5) criteria for major depressive disorder (MDD)
  • * have experienced a perinatal loss (including early and late fetal death, death of a liveborn neonate within the first 28 days, and medically recommended termination) within the last 1-12 months
  • * are 18 to 50 years old
  • * speak and understand English well enough to understand questionnaires when they are read aloud
  • * can provide the name and contact information of at least two locator persons
  • * have access to a telephone through owning one, a relative/friend, or an agency
  • * onset of current major depressive episode prior to news of difficulties with the pregnancy or health risk to the infant (women with prior episodes will be included)
  • * current or past diagnosis of bipolar disorder, schizophrenia or other psychotic disorder
  • * primary diagnosis of current substance use disorder
  • * acute suicidal or homicidal risk
  • * non-stable course of antidepressant medication or psychotherapy (i.e., beginning or changing dose of either within the previous 12 weeks)
  • * any IPT or cognitive-behavioral treatment in the previous 12 weeks

Ages Eligible for Study

18 Years to 50 Years

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

No

Collaborators and Investigators

Michigan State University,

Jennifer E Johnson, PhD, PRINCIPAL_INVESTIGATOR, Michigan State University

Study Record Dates

2025-11-01