RECRUITING

NOX4 and Related Biomarkers in ADPKD

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

To determine the value of NOX4, markers of mitochondria injury and function, and oxidative stress as real-time biomarkers to assess disease severity in patients with early autosomal dominant polycystic kidney disease (ADPKD).

Official Title

NOX4, Mitochondria and Related Biomarkers in Autosomal Dominant Polycystic Kidney Disease

Quick Facts

Study Start:2020-07-21
Study Completion:2025-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04630613

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:15 Years to 40 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Not specified
Standard Ages:CHILD, ADULT
Inclusion CriteriaExclusion Criteria
  1. * ADPKD (based on Ravine et al. criteria)
  2. * Class 1 A-E according to imaging classification
  3. * Male and female subjects 15 - 40 years of age
  4. * Estimated GFR\> 70 mL/min/1.73 m2 (CKD-EPI)
  5. * Ability to provide written, informed consent
  1. * Class 2 according to imaging classification
  2. * Concomitant systemic disease affecting the kidney
  3. * Diabetes mellitus
  4. * Predicted urine protein excretion in \>1 g/24 hrs
  5. * Use of antioxidants i.e. vitamins, Nrf2 activators
  6. * Abnormal urinalysis

Contacts and Locations

Principal Investigator

Maria V Irazabal, M.D., Ph.D.
PRINCIPAL_INVESTIGATOR
Mayo Clinic

Study Locations (Sites)

Mayo Clinic
Rochester, Minnesota, 55905
United States

Collaborators and Investigators

Sponsor: Mayo Clinic

  • Maria V Irazabal, M.D., Ph.D., PRINCIPAL_INVESTIGATOR, Mayo Clinic

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2020-07-21
Study Completion Date2025-12

Study Record Updates

Study Start Date2020-07-21
Study Completion Date2025-12

Terms related to this study

Keywords Provided by Researchers

  • Oxidative Stress
  • Mitochondria injury and function
  • NADPH oxidase 4

Additional Relevant MeSH Terms

  • Autosomal Dominant Polycystic Kidney Disease