Prolonged Pulsatile Kisspeptin Administration in Hypogonadotropic Hypogonadism

Eligibility Criteria

• * Age 18 years and older,
• * Confirmed diagnosis of HH with
• * Low testosterone or estradiol,
• * Low or low-normal gonadotropin levels,
• * Thyroid stimulating hormone (TSH) and prolactin within the reference range,
• * Absence of abnormal pituitary or hypothalamic findings on Magnetic resonance imaging (MRI),
• * All other medical conditions stable and well controlled,
• * No prescription medications known to affect reproductive endocrine function for at least 2 months or for 5 half-lives of the drug (whichever is shorter) except for medications used to treat the subject's reproductive condition,
• * No history of a medication reaction requiring emergency medical care,
• * No illicit drug use,
• * No excessive alcohol consumption (\<10 drinks/week),
• * Normal blood pressure (BP), (systolic BP \< 140 mm Hg, diastolic \< 90 mm Hg),
• * White blood cell, platelet counts, and TSH between 90% of the lower limit and 110% of the upper limit of the reference range,
• * Prolactin below 110% of the upper limit of the reference range,
• * Hemoglobin
• * Women: no less than 0.5 gm/dL below the lower limit of the reference range for normal women,
• * Men: on adequate testosterone replacement therapy: normal male reference range,
• * Blood urea nitrogen (BUN), creatinine, aspartate aminotransferase (AST), alanine transaminase (ALT) not elevated,
• * For women,
• * Negative serum human chorionic gonadotropin (hCG) pregnancy test at the time of screening (additional urine pregnancy test will be conducted prior to drug administration),
• * Not breastfeeding and not pregnant.