RECRUITING

4D-MRI for Precision Medicine

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to develop new ways to make medical images of the lungs and liver of adults using a technique called four-dimensional magnetic resonance imaging (4D-MRI). This technique produces three-dimensional movies of the inside of the chest and abdomen while the patient is breathing. (The fourth dimension is time!) This new way of medical imaging is being developed to help cancer patients undergoing radiation therapy. Radiation therapy is used to treat cancerous tumors. For radiation therapy to be effective, the precise size, shape, and location of the tumor within the body must be known. A particular difficulty for radiation treatment of lung and liver cancer is that the tumor moves during treatment because the patient is breathing. Therefore, tumor motion must also be incorporated into the treatment plan. This study aims to improve radiation treatment planning through better targeting and dose estimation based on 4D-MRI. Before this new imaging method can be used for radiation treatment planning, it must be tested in living, breathing volunteers.

Official Title

Toward Precision Radiotherapy: Physiological Modeling of Respiratory Motion Based on Ultra-quality 4D-MRI

Quick Facts

Study Start:2020-11-05
Study Completion:2025-12-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04657042

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 82 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Patient is 21 or older
  2. * Patient has primary or metastatic tumor(s) in the lungs or the liver
  3. * Diameter of the tumor(s) is less than 7 cm
  4. * Patient will receive radiation therapy (ordered by the treating Radiation Oncologist) as part of their treatment regimen
  5. * Patient will undergo a planning CT scan with tumor motion assessment (planning 4D-CT ordered by the treating Radiation Oncologist) as part of their treatment regimen
  6. * Patient has signed informed consent and is willing to comply with the 4D-MRI imaging protocol
  7. * Subject is 18 or older
  8. * Subject has signed informed consent and is willing to comply with the 4D-MRI imaging protocol
  1. * Any condition for which a MRI procedure is contraindicated including presence of metallic material in the body, such as pacemakers, non- MRI compatible surgical clips, shrapnel, etc.
  2. * Subjects who have difficulty lying flat on their back for extended periods of time
  3. * Patients with any serious/poorly controlled medical or psychological conditions that would complicate protocol compliance
  4. * Too large to adequately fit in the magnet bore or RF coils
  5. * Claustrophobia
  6. * Females who are pregnant or lactating
  7. * Presence of active or chronic infection

Contacts and Locations

Study Contact

Roselove N Nunoo-Asare, MA
CONTACT
4342436074
RNN3B@VIRGINIA.EDU

Principal Investigator

G. Wilson Miller, PhD
PRINCIPAL_INVESTIGATOR
Univsersity of Virginia

Study Locations (Sites)

University of Virginia
Charlottesville, Virginia, 22908
United States

Collaborators and Investigators

Sponsor: University of Virginia

  • G. Wilson Miller, PhD, PRINCIPAL_INVESTIGATOR, Univsersity of Virginia

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2020-11-05
Study Completion Date2025-12-31

Study Record Updates

Study Start Date2020-11-05
Study Completion Date2025-12-31

Terms related to this study

Additional Relevant MeSH Terms

  • Healthy Volunteers
  • Liver Cancer
  • Lung Cancer