Neural Circuit Biomarkers of Transcranial Magnetic Stimulation Study

Description

This study is currently recruiting Veterans only. The objective of this observational study is to test whether neuroimaging biomarkers of repetitive transcranial magnetic stimulation (TMS) can be prospectively replicated in a large ecologically valid sample. We focus on cognitive network connectivity as a predictive biomarker of the clinical effect of TMS, and as a response biomarker of change with TMS. We address this objective through a pragmatic approach in which we recruit patients undergoing routine clinical care and program evaluation in a Veterans Administration multi-site clinical TMS program.

Conditions

Depression

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Study Overview

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Study Details

Study overview

This study is currently recruiting Veterans only. The objective of this observational study is to test whether neuroimaging biomarkers of repetitive transcranial magnetic stimulation (TMS) can be prospectively replicated in a large ecologically valid sample. We focus on cognitive network connectivity as a predictive biomarker of the clinical effect of TMS, and as a response biomarker of change with TMS. We address this objective through a pragmatic approach in which we recruit patients undergoing routine clinical care and program evaluation in a Veterans Administration multi-site clinical TMS program.

Mechanistic Circuit Markers of Transcranial Magnetic Stimulation Outcomes in Pharmacoresistant Depression

Neural Circuit Biomarkers of Transcranial Magnetic Stimulation Study

Condition
Depression
Intervention / Treatment

-

Contacts and Locations

Stanford

Stanford University Department of Psychiatry, Stanford, California, United States, 94305

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Ages 18 years and older
  • * Meets Diagnostic and Statistical Manual edition 5 (DSM-5) criteria for Major Depressive Disorder (MDD) (as documented by the treating physician)
  • * Meet study criteria for pharmacoresistance in accordance with the Clinical transcranial magnetic stimulation (TMS) Program (i.e. failed at least one antidepressant in the current episode)
  • * Ability to obtain a motor threshold (MT) prior to the start of treatment
  • * Stable medical conditions and ability to maintain stability on current medication regimen for the duration of treatment
  • * Ability to participate in a daily treatment regimen
  • * Able to read, verbalize understanding, and voluntarily sign the Informed Consent Form prior to participating in any study-specific procedures or assessments
  • * History of seizure disorder
  • * Structural or neurologic abnormalities present or in close proximity to the treatment site
  • * History of brain surgery
  • * Pacemaker or medical infusion device (unless magnetic resonance imaging compatible)
  • * History of traumatic brain injury within 60 days of the start of treatment
  • * Severe or uncontrolled alcohol or substance use disorders
  • * Active withdrawal from alcohol or substances
  • * Implanted device in the head
  • * Metal in the head
  • * Severe impediment to vision, hearing and/or hand movement, likely to interfere with ability to complete the assessments, or unable and/or unlikely to follow the study protocols
  • * Lifetime history of bipolar I disorder
  • * Inability to speak, read or understand English
  • * Plans to move out of the area during the study period
  • * Clinician and/or Investigator discretion for clinical safety or protocol adherence

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Stanford University,

Leanne Williams, PhD, PRINCIPAL_INVESTIGATOR, Stanford University

Study Record Dates

2026-12-31