Mechanisms for Activation of Beige Adipose Tissue in Humans

Description

Mirabegron (Myrbetriq®, Astellas) is a highly specific and well-tolerated ß3 agonist marketed for overactive bladder. This trial will assess the effects of mirabegron on glucose tolerance and adipose tissue in prediabetic patients

Conditions

PreDiabetes

Study Overview

Study Details

Study overview

Mirabegron (Myrbetriq®, Astellas) is a highly specific and well-tolerated ß3 agonist marketed for overactive bladder. This trial will assess the effects of mirabegron on glucose tolerance and adipose tissue in prediabetic patients

Mechanisms for Activation of Beige Adipose Tissue in Humans

Mechanisms for Activation of Beige Adipose Tissue in Humans

Condition
PreDiabetes
Intervention / Treatment

-

Contacts and Locations

Lexington

University of Kentucky, Lexington, Kentucky, United States, 40536

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * BMI 27-45
  • * prediabetes (A1c 5.7-6.4)
  • * impaired fasting glucose or impaired glucose tolerance
  • * diabetes
  • * chronic use of anti-diabetic medication
  • * acute or chronic inflammatory condition
  • * unstable medical condition
  • * cancer
  • * renal insufficiency
  • * any contraindication for Mirabegron
  • * BMI \>45

Ages Eligible for Study

35 Years to 65 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Philip Kern,

Philip Kern, MD, PRINCIPAL_INVESTIGATOR, University of Kentucky

Study Record Dates

2024-12-31