RECRUITING

Mechanisms for Activation of Beige Adipose Tissue in Humans

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Mirabegron (Myrbetriq®, Astellas) is a highly specific and well-tolerated ß3 agonist marketed for overactive bladder. This trial will assess the effects of mirabegron on glucose tolerance and adipose tissue in prediabetic patients

Official Title

Mechanisms for Activation of Beige Adipose Tissue in Humans

Quick Facts

Study Start:2020-12-07
Study Completion:2024-12-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04666636

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:35 Years to 65 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * BMI 27-45
  2. * prediabetes (A1c 5.7-6.4)
  3. * impaired fasting glucose or impaired glucose tolerance
  1. * diabetes
  2. * chronic use of anti-diabetic medication
  3. * acute or chronic inflammatory condition
  4. * unstable medical condition
  5. * cancer
  6. * renal insufficiency
  7. * any contraindication for Mirabegron
  8. * BMI \>45

Contacts and Locations

Study Contact

Philip Kern, MD
CONTACT
859-323-5821
pake222@uky.edu

Principal Investigator

Philip Kern, MD
PRINCIPAL_INVESTIGATOR
University of Kentucky

Study Locations (Sites)

University of Kentucky
Lexington, Kentucky, 40536
United States

Collaborators and Investigators

Sponsor: Philip Kern

  • Philip Kern, MD, PRINCIPAL_INVESTIGATOR, University of Kentucky

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2020-12-07
Study Completion Date2024-12-31

Study Record Updates

Study Start Date2020-12-07
Study Completion Date2024-12-31

Terms related to this study

Keywords Provided by Researchers

  • beige
  • adipose
  • glucose
  • fat
  • BAT
  • diabetes
  • metabolism
  • DEXA

Additional Relevant MeSH Terms

  • PreDiabetes