Role of Diet on the Microbiome of the Digestive System

Description

This study is to learn more about how diet affects the microbiome (bacteria and microorganisms) of the digestive system. Researchers want to learn if this, in turn, has an effect on if and how people then develop colorectal cancer.

Conditions

Colorectal Carcinoma

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Study Overview

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Study Details

Study overview

This study is to learn more about how diet affects the microbiome (bacteria and microorganisms) of the digestive system. Researchers want to learn if this, in turn, has an effect on if and how people then develop colorectal cancer.

The Role of Diet and the Microbiome in Inducing Somatic Mutations in Colorectal Epithelial Cells and Its Predisposition to Carcinogenesis - A Pilot Study

Role of Diet on the Microbiome of the Digestive System

Condition
Colorectal Carcinoma
Intervention / Treatment

-

Contacts and Locations

Houston

M D Anderson Cancer Center, Houston, Texas, United States, 77090

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * GROUP I: Patients presenting for a screening colonoscopy
  • * GROUP I: Age of 45 and above
  • * GROUP I: Strict vegetarian diet, determined by using diet history questionnaire 3.0 National Institutes of Health (NIH)
  • * GROUP I: Non smoker
  • * GROUP I: Ability to understand and willingness to sign an informed consent form, complete web based dietary assessment and provide stool, colonic mucosa and blood samples
  • * GROUP II: Patients presenting for a screening colonoscopy
  • * GROUP II: Age of 45 and above
  • * GROUP II: Omnivorous diet
  • * GROUP II: Non smoker
  • * GROUP II: Ability to understand and willingness to sign an informed consent form, complete web based dietary assessment and provide stool, colonic mucosa and blood sample
  • * • Current smokers (nicotine abuse only)
  • * Positive family history of colon cancer or colon cancer related syndromes
  • * Recent use of antibiotics in 1 month
  • * History of inflammatory bowel disease, and/or radiation enteritis or colitis
  • * Pregnant and breastfeeding women
  • * Women of child-bearing potential who have positive urine or serum pregnancy test
  • * Heavy drinker (defined as more than 14 drinks per week)
  • * Currently using anti-flatulence medications, probiotics and/or fiber supplements
  • * Major dietary restrictions and/or following a special diet
  • * Patient with positive fecal test/symptoms

Ages Eligible for Study

45 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

M.D. Anderson Cancer Center,

Anusha Thomas, MD, PRINCIPAL_INVESTIGATOR, MD Anderson Cancer Center, Houston, Texas

Study Record Dates

2026-01-01