COMPLETED

Fitness for Brain Optimization for Late-Life Depression

Conditions

Depression in Old Age Depression Exercise Late-Life Cognitive Impairment Brain Health

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Cognitive impairment and brain abnormalities are common and persist after depression remission in those with Late Life Depression (LLD), compounding dementia risk in both individuals with acute and remitted LLD (rLLD). In this study, investigators will examine systemic neural and cognitive benefits of aerobic exercise training in older adults with remitted LLD. This will generate preliminary data regarding neural targets of aerobic exercise training that may translate to cognitive benefits in those with rLLD, a population who remains at high risk for dementia despite successful treatment of depression.

Official Title

Aerobic Exercise for Optimizing Cognitive and Brain Health in Remitted Late-Life Depression

Quick Facts

Study Start:2021-08-04

Study Completion:2025-10-22

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:COMPLETED

Study ID

NCT04670510

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:60 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:No

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
1. Men and women 60+ years 2. Major Depressive Episode in older adulthood (since age 55) 3. Current level of depressive symptoms does not meet criteria for a Major Depressive Episode 4. Ambulatory without pain or the assistance of walking devices 5. Able to speak and read English 6. Exercise level of \<100 minutes per week on average 7. Medical clearance by primary care physician (PCP) 8. Living in community for duration of the study 9. Reliable means of transportation 10. No diagnosis of a neurological disease 11. Eligible to undergo MRI	1. Current diagnosis of a Major Depressive Episode 2. Psychosis 3. Significant suicide risk (i.e., current, active suicidal ideation with a plan) 4. Electroconvulsive therapy within the past 12 months 5. Engaging in moderate-intensity exercise \>100 minutes per week on average 6. Current treatment for cancer - except non-melanoma skin 7. Neurological condition (MS, Parkinson's, Dementia, MCI) or brain injury (Stroke) 8. Substance Use disorder in the past 3-months 9. Current treatment for congestive heart failure, angina, uncontrolled arrhythmia, deep vein thromboses (DVT) or other cardiovascular event 10. Myocardial infarction, coronary artery bypass grafting, angioplasty or other cardiac condition in the past year including uncontrolled hypertension 11. Regular use of an assisted walking device 12. Presence of metal implants (pacemaker, stents) that would be MR ineligible 13. Claustrophobia 14. Color Blindness 15. Significant visual or hearing impairments that would preclude neuropsychological assessment or communication with study staff via a virtual format (videoteleconference) 16. Not fluent in English 17. Not medically cleared by PCP 18. Traveling consecutively for 3+ weeks during the study 19. MOCA (\<20 to exclude) and MADRS (\>9 to exclude)

Inclusion Criteria

Exclusion Criteria

1. Men and women 60+ years
2. Major Depressive Episode in older adulthood (since age 55)
3. Current level of depressive symptoms does not meet criteria for a Major Depressive Episode
4. Ambulatory without pain or the assistance of walking devices
5. Able to speak and read English
6. Exercise level of \<100 minutes per week on average
7. Medical clearance by primary care physician (PCP)
8. Living in community for duration of the study
9. Reliable means of transportation
10. No diagnosis of a neurological disease
11. Eligible to undergo MRI

1. Current diagnosis of a Major Depressive Episode
2. Psychosis
3. Significant suicide risk (i.e., current, active suicidal ideation with a plan)
4. Electroconvulsive therapy within the past 12 months
5. Engaging in moderate-intensity exercise \>100 minutes per week on average
6. Current treatment for cancer - except non-melanoma skin
7. Neurological condition (MS, Parkinson's, Dementia, MCI) or brain injury (Stroke)
8. Substance Use disorder in the past 3-months
9. Current treatment for congestive heart failure, angina, uncontrolled arrhythmia, deep vein thromboses (DVT) or other cardiovascular event
10. Myocardial infarction, coronary artery bypass grafting, angioplasty or other cardiac condition in the past year including uncontrolled hypertension
11. Regular use of an assisted walking device
12. Presence of metal implants (pacemaker, stents) that would be MR ineligible
13. Claustrophobia
14. Color Blindness
15. Significant visual or hearing impairments that would preclude neuropsychological assessment or communication with study staff via a virtual format (videoteleconference)
16. Not fluent in English
17. Not medically cleared by PCP
18. Traveling consecutively for 3+ weeks during the study
19. MOCA (\<20 to exclude) and MADRS (\>9 to exclude)

Contacts and Locations

Principal Investigator

Swathi Gujral, PhD

PRINCIPAL_INVESTIGATOR

University of Pittsburgh

Study Locations (Sites)

UPMC Western Psychiatric Hospital

Pittsburgh, Pennsylvania, 15213

United States

Collaborators and Investigators

Sponsor: University of Pittsburgh

Swathi Gujral, PhD, PRINCIPAL_INVESTIGATOR, University of Pittsburgh

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-08-04

Study Completion Date2025-10-22

Study Record Updates

Study Start Date2021-08-04

Study Completion Date2025-10-22

Terms related to this study

Keywords Provided by Researchers

Depression
Exercise
Late-Life
Cognitive Impairment
Brain Health

Additional Relevant MeSH Terms

Depression in Old Age