Assessment of the Efficacy of Medrol Dose Pack for Acute Post-Concussive Headaches

Description

This novel pilot project will assess the effectiveness of corticosteroids in treatment of acute post-concussion headache. The investigators hypothesize that the use of corticosteroids will cause significant headache reduction in frequency and/or intensity than individuals who undergo the current standard of care. Additionally, the investigators hypothesize that corticosteroid use will lead to a reduction in other somatic symptoms including vestibular symptoms, leading to quicker return to school, work, and/or ability to play sports.

Conditions

Post-Concussion Syndrome, Headache

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Study Overview

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Study Details

Study overview

This novel pilot project will assess the effectiveness of corticosteroids in treatment of acute post-concussion headache. The investigators hypothesize that the use of corticosteroids will cause significant headache reduction in frequency and/or intensity than individuals who undergo the current standard of care. Additionally, the investigators hypothesize that corticosteroid use will lead to a reduction in other somatic symptoms including vestibular symptoms, leading to quicker return to school, work, and/or ability to play sports.

Assessment of the Efficacy of Medrol Dose Pack for Post-Concussive Headaches

Assessment of the Efficacy of Medrol Dose Pack for Acute Post-Concussive Headaches

Condition
Post-Concussion Syndrome
Intervention / Treatment

-

Contacts and Locations

Manhasset

Northwell Health - North Shore University Hospital, Manhasset, New York, United States, 11030

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Provision of signed and dated informed consent form (in person or via telehealth)
  • 2. Stated willingness to comply with all study procedures and availability for the duration of the study
  • 3. Male or female, aged \>18 years old
  • 4. Ability to take oral medication and be willing to adhere to the study regimen as described in this protocol
  • 5. Patients presenting with all types of post-concussive headache with \>5/10 in severity on the numerical analog scale.
  • 6. Headache that occurs for \> 4 hours per day
  • 7. Headache that occurs every day
  • 8. Headache that began after concussion, patient was diagnosed at an outpatient clinic or was hospitalized
  • 9. Headache developed within 7 days post-injury and patient presenting within 30 days from initial trauma
  • 10. A diagnosis of concussion.
  • 11. If a patient is taking another pain medication, this still be included in the stud
  • 1. Any evidence of known intracranial hemorrhage on neuroimaging
  • 2. Headache developing after 7 days post injury and patient presenting after 30 days from initial trauma
  • 3. Headache occurs \< 4 hours per day
  • 4. Headache does not occur daily
  • 5. Age \< or = 18
  • 6. Headache is \< 5 in severity on numerical analog scale
  • 7. Presence of increase in intracranial pressure or papilledema
  • 8. Any contraindication to corticosteroids
  • 9. Allergy or sensitivity to corticosteroids
  • 10. Active Tuberculosis
  • 11. Active pregnancy
  • 12. Currently on corticosteroids for another reason
  • 13. Participants with fungal infection

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Northwell Health,

Jamie S Ullman, MD, PRINCIPAL_INVESTIGATOR, Hofstra Northwell School of Medicine

Study Record Dates

2026-12-01