Impacts of Nicotinamide Riboside on Functional Capacity and Muscle Physiology in Older Veterans

Description

Frailty is an age-associated clinical condition of poor physiological reserve that increases risks for falls, hospitalization and mortality. Nicotinamide adenine dinucleotide (NAD) is a critical co-factor needed for many cellular processes. The natural levels of NAD decline aging and this has been linked to physical performance decline in animals. Human trials have demonstrated that nicotinamide riboside (NR), a form of vitamin B3, is safe and effectively increases NAD+ levels. In animal studies, NR improves treadmill performance and muscle quality. Here the investigators propose a double-blind randomized control trial to assess the benefits of NR supplementation on human muscle function and physiology. The investigators anticipate the research findings will support the use of this nutritional supplement to improve the health of Veterans during aging.

Conditions

Sarcopenia, Nicotinamide Adenine Dinucleotide Concentration, Muscle Quality and NAD+ Content

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Study Overview

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Study Details

Study overview

Frailty is an age-associated clinical condition of poor physiological reserve that increases risks for falls, hospitalization and mortality. Nicotinamide adenine dinucleotide (NAD) is a critical co-factor needed for many cellular processes. The natural levels of NAD decline aging and this has been linked to physical performance decline in animals. Human trials have demonstrated that nicotinamide riboside (NR), a form of vitamin B3, is safe and effectively increases NAD+ levels. In animal studies, NR improves treadmill performance and muscle quality. Here the investigators propose a double-blind randomized control trial to assess the benefits of NR supplementation on human muscle function and physiology. The investigators anticipate the research findings will support the use of this nutritional supplement to improve the health of Veterans during aging.

Impacts of Nicotinamide Riboside on Functional Capacity and Muscle Physiology in Older Veterans

Impacts of Nicotinamide Riboside on Functional Capacity and Muscle Physiology in Older Veterans

Condition
Sarcopenia
Intervention / Treatment

-

Contacts and Locations

Kansas City

Kansas City VA Medical Center, Kansas City, MO, Kansas City, Missouri, United States, 64128-2226

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Ages 65-85
  • * Male or female
  • * Any race
  • * Ability to use an exercise bike
  • * Medically cleared for muscle biopsy
  • * Severe Co-morbidity
  • * examples include, but not limited to:
  • * congestive heart failure class equal to or above III
  • * chronic obstructive pulmonary disorder (COPD) gold stage IV
  • * chronic kidney disease equal to or above stage
  • * A VA-SLUMS cognitive screen score of less than or equal to 20
  • * Body mass index greater than or equal to 40

Ages Eligible for Study

65 Years to 85 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

VA Office of Research and Development,

Kenneth L Seldeen, PhD, PRINCIPAL_INVESTIGATOR, Kansas City VA Medical Center, Kansas City, MO

Study Record Dates

2026-06-30