Ommaya Reservoir Placement for Brain Tumor Biomarker Access

Description

The purpose of this study is to determine the safety and feasibility of intra-operative Ommaya Reservoir placement during a clinically indicated operation for brain tumor. The Ommaya reservoir will facilitate a longitudinal access to cerebrospinal fluid (CSF) for analysis of potential biomarkers for brain tumor research and individualized monitoring.

Conditions

Brain Tumor

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Study Overview

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Study Details

Study overview

The purpose of this study is to determine the safety and feasibility of intra-operative Ommaya Reservoir placement during a clinically indicated operation for brain tumor. The Ommaya reservoir will facilitate a longitudinal access to cerebrospinal fluid (CSF) for analysis of potential biomarkers for brain tumor research and individualized monitoring.

Ommaya Reservoir Placement for Brain Tumor Biomarker Access

Ommaya Reservoir Placement for Brain Tumor Biomarker Access

Condition
Brain Tumor
Intervention / Treatment

-

Contacts and Locations

Rochester

Mayo Clinic in Rochester, Rochester, Minnesota, United States, 55905

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age \> 18 years.
  • * Clinical and radiographic evidence suggesting a diagnosis of a brain tumor.
  • * Planned neurosurgical procedure resection of suspected or previously diagnosed brain tumor as part of routine clinical care.
  • * Willing to undergo neurosurgical resection at Mayo Clinic (Rochester, MN).
  • * Ability to understand and the willingness to sign a written informed consent document.
  • * Patient is willing to have their Ommaya sampled on at least 2 future occasions.
  • * Patients is willing to have CSF banked through the neuro-oncology biorepository (requires a separate signature)
  • * Vulnerable populations including pregnant women, prisoners and individuals \<18 years old.
  • * Patients who are not appropriate candidates for surgery due to current or past medical history or uncontrolled concurrent illness.
  • * Prior history of any wound infection
  • * Any patient who the surgeon feels is not an optimal candidate for Ommaya reservoir placement. Such reasons could (but need not necessarily) include factors related to surgical anatomy, clinical evidence of significant immunosuppression, and/or elevated risk of wound infection due to diabetes, smoking history, morbid obesity, or any other concerns.

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Mayo Clinic,

Terry C. Burns, MD, PhD, PRINCIPAL_INVESTIGATOR, Mayo Clinic

Study Record Dates

2025-12-31