LITT Followed by Hypofractionated RT for Newly Diagnosed Gliomas (GCC 20138)

Description

The purpose of this study is to evaluate the treatment regimen of using Laser Interstitial Thermal Therapy (LITT) and Hypo-fractionated Radiation Therapy to treat patients with newly diagnosed gliomas.

Conditions

Glioma, Glioblastoma, Brain Tumor

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Study Overview

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Study Details

Study overview

The purpose of this study is to evaluate the treatment regimen of using Laser Interstitial Thermal Therapy (LITT) and Hypo-fractionated Radiation Therapy to treat patients with newly diagnosed gliomas.

Laser Interstitial Thermal Therapy Followed By Hypofractionated Radiation Therapy For Treatment Of Newly Diagnosed High-Grade Gliomas

LITT Followed by Hypofractionated RT for Newly Diagnosed Gliomas (GCC 20138)

Condition
Glioma
Intervention / Treatment

-

Contacts and Locations

Baltimore

Maryland Proton Treatment Center, Baltimore, Maryland, United States, 21201

Baltimore

University of Maryland Greenebaum Cancer Center, Baltimore, Maryland, United States, 21201

Bel Air

UCH Kaufman Cancer Center, Bel Air, Maryland, United States, 21014

Columbia

Central Maryland Radiation Oncology, Columbia, Maryland, United States, 21044

Glen Burnie

Baltimore Washington Medical Center, Glen Burnie, Maryland, United States, 21061

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Patients with radiographic evidence of suggestive of a primary high-grade glioma
  • 2. Brain MRI with contrast demonstrates an enhancing mass within 60 days prior to registration. Patient must be deemed a candidate for LITT from MRI by Neurosurgery in order to be eligible.
  • 3. History and physical including neurological exam within 30 days prior to registration
  • 4. Karnofsky performance status ≥50% within 30 days prior to registration
  • 5. Age ≥ 18 years old
  • 6. Patients must have signed an approved informed consent
  • 7. Patients with the potential for pregnancy or impregnating their partner must agree to practice effective contraceptive methods to avoid conception while on study and for 6 months after study completion.
  • 8. Female patients of child-bearing potential must have a negative pregnancy test within 28 days prior to study registration.
  • 1. Patients that are not surgical candidates for stereotactic biopsy or laser ablation
  • 2. Patients with impaired cardiac function or clinically significant cardiac diseases, including any of the following:
  • * History or presence of serious uncontrolled ventricular or significant arrhythmias.
  • * Any of the following within 6 months prior to registration: myocardial infarction, severe/unstable angina, coronary artery bypass graft, congestive heart failure, cerebrovascular accident, transient ischemic attack , pulmonary embolism
  • 3. Infratentorial tumor or evidence of leptomeningeal spread
  • 4. Inability to undergo a MRI
  • 5. Pregnant or breast-feeding women

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Maryland, Baltimore,

Study Record Dates

2027-12