RECRUITING

TATE and Pembrolizumab (MK3475) in mCRC and NSCLC

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Patients with refractory metastatic colorectal cancer or non-small cell lung cancer with liver metastasis treated with Trans-arterial Tirapazamine Embolization along with Pembrolizumab.

Official Title

An Open Label Phase II Study for the Treatment of Liver Metastatic Colorectal Cancer and Non-Small Cell Lung Cancer With a Combination of TATE (Trans-Arterial Tirapazamine Embolization) and Pembrolizumab

Quick Facts

Study Start:2021-05-20
Study Completion:2025-12-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04701476

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Liver metastatic MSS-mCRC or NSCLC without EGFR or AKT mutations
  2. * mCRC progressed on at least two lines of standard chemotherapy; or
  3. * NSCLC progressed on chemotherapy and an immune checkpoint inhibitor
  4. * Measurable disease
  5. * ECOG 0-1
  6. * At least 4 weeks from prior chemotherapy and free from chemo-related toxicity
  7. * Adequate organ function
  1. * Prior organ transplantation
  2. * Liver metastasis more than 50%
  3. * Oxygen saturation less than 92% in room air
  4. * Prior autoimmune disorder
  5. * CNS metastasis
  6. * Major GI bleeding in the last 2 months

Contacts and Locations

Study Contact

Ray Lee, MD. PhD.
CONTACT
8043341076
ray.lee01@teclison.com
Chiwei Lu
CONTACT
chiwei.lu4@teclison.com

Principal Investigator

Ray Lee
STUDY_DIRECTOR
Teclison Limited

Study Locations (Sites)

University of California, Irvine Medical Center
Orange, California, 92868
United States

Collaborators and Investigators

Sponsor: Teclison Ltd.

  • Ray Lee, STUDY_DIRECTOR, Teclison Limited

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-05-20
Study Completion Date2025-12-31

Study Record Updates

Study Start Date2021-05-20
Study Completion Date2025-12-31

Terms related to this study

Keywords Provided by Researchers

  • colorectal cancer
  • NSCLC
  • pembrolizumab
  • tirapazamine
  • Liver metastasis

Additional Relevant MeSH Terms

  • Colorectal Cancer; Lung Cancer