Pregabalin vs. Gabapentin on Reducing Opioid Usage

Description

This is a single-center, randomized, open-label, Phase 4 clinical trial investigating the efficacy of multiple-dose administrations of Pregabalin or Gabapentin in combination with traditional opioid pain medications to decrease the amount of opioid pain medication usage in single-system orthopedic trauma patients.

Conditions

Analgesics, Gabapentin, Injuries, Narcotics, Pain, Trauma

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Study Overview

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Study Details

Study overview

This is a single-center, randomized, open-label, Phase 4 clinical trial investigating the efficacy of multiple-dose administrations of Pregabalin or Gabapentin in combination with traditional opioid pain medications to decrease the amount of opioid pain medication usage in single-system orthopedic trauma patients.

Pregabalin vs. Gabapentin on Reducing Opioid Usage in Trauma Patients

Pregabalin vs. Gabapentin on Reducing Opioid Usage

Condition
Analgesics
Intervention / Treatment

-

Contacts and Locations

Charleston

Charleston Area Medical Center"s Level 1 Trauma Center, Charleston, West Virginia, United States, 25301

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Nurse Practitioner service admissions
  • 2. 18 years of age or older
  • 3. Patients enrolled within 36 hours of admission
  • 4. Anticipated duration of hospitalization \> 24 hours from time of consent
  • 5. Active order(s) for opioids in place at the time of enrollment
  • 1. Clinician discretion based on patient care management
  • 2. Intubated patients
  • 3. Patients with epidural
  • 4. Patients with pregabalin/gabapentin as home medications
  • 5. Patients receiving pregabalin/gabapentin upon admission
  • 6. Traumatic brain injury patients
  • 7. CrCl\<30ml/min or on HD
  • 8. Unable to take enteral medications
  • 9. On Patient Controlled Analgesia (PCA)
  • 10. Patients with complicated wound closure
  • 11. History of epilepsy
  • 12. Documented history of substance use disorder

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

CAMC Health System,

Study Record Dates

2025-12-31