DMSO Cryopreserved Platelets in Cardiopulmonary Bypass Surgery (CRYPTICS)

Eligibility Criteria

• 1. Male or female, at least 18 years of age
• 2. Undergoing CPB surgery with at least one risk factor for post-surgical bleeding including:
• 1. All re-operative cardiac procedures.
• 2. Expected bypass \> 120 minutes.
• 3. Any combined cardiac surgery procedures (e.g. multiple valve, valve/CABG).
• 4. Any procedure that in the estimation of the surgical attending, has a high likelihood of receiving platelets
• 3. Ability to comprehend and willingness to sign informed consent.
• 4. If female of childbearing potential, have a negative pregnancy test on the day of the surgery and prior to the surgery agrees to use a method of highly effective birth control from the time of consent through the end of the safety follow-up period (Day 6 or discharge from hospital, whichever is earlier). Note: women must have been surgically sterilized \[bilateral tubal ligation, bilateral oophorectomy, total hysterectomy) or postmenopausal (≥50 years of age and continuous amenorrhea for 24 months) to be considered non-childbearing potential.
• 1. Undergoing any of the following surgical procedures:
• 1. Coronary artery bypass surgery alone
• 2. Implantation of ventricular assist device
• 3. Thoracoabdominal aortic aneurysm repair
• 2. Known or suspected pregnancy or breastfeeding
• 3. History of any major unprovoked thrombotic events
• 4. History of heparin-inducted thrombocytopenia
• 5. Active infection treated with antibiotics
• 6. Refuse transfusion of blood products for religious or other reasons
• 7. Previous enrollment in this study
• 8. Immune thrombocytopenic purpura
• 9. Known allergy to DMSO
• 10. In the judgement of the investigator, is not a good candidate for the study