Effects of CPAP Therapy on Blood Pressure and Heart Rate Variability in Obstructive Sleep Apnea

Description

The primary objective of this study is to determine whether the effect of continuous positive airway pressure (CPAP) therapy on 24-hour mean blood pressure (BP) in patients with obstructive sleep apnea (OSA) varies between symptom phenotypes.

Conditions

Sleep Apnea, Obstructive

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Study Overview

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Study Details

Study overview

The primary objective of this study is to determine whether the effect of continuous positive airway pressure (CPAP) therapy on 24-hour mean blood pressure (BP) in patients with obstructive sleep apnea (OSA) varies between symptom phenotypes.

Effects of CPAP Therapy on Blood Pressure and Heart Rate Variability in Obstructive Sleep Apnea: Role of Symptom Subtypes

Effects of CPAP Therapy on Blood Pressure and Heart Rate Variability in Obstructive Sleep Apnea

Condition
Sleep Apnea, Obstructive
Intervention / Treatment

-

Contacts and Locations

Columbus

Martha Morehouse Medical Pavilion, Suite 2600, Columbus, Ohio, United States, 43221

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * 30 to 75 years of age
  • * Among patients with hypertension, no change in BP medication for at least 3 months.
  • * Willing and able to give informed consent
  • * Willing and able to complete ambulatory blood pressure monitoring at baseline and after 6-months.
  • * Sleep study \[Polysomnography (PSG) or Home Sleep Apnea Study (HSAT) performed based on clinical grounds
  • * 4% oxygen desaturation index (ODI4) ≥15 events/hour on clinical sleep study
  • * Planned CPAP treatment by treating provider
  • * Unable to apply BP cuff (e.g. arm circumference \>55 cm, prior breast cancer, structural abnormalities of the arm)
  • * Current use of CPAP or Dental Device for OSA
  • * Category III-IV of heart failure
  • * Presence of Cheyne-Stokes Respiration (CSR) in PSG
  • * Predominantly central sleep apnea (AHI≥15 events/hour)
  • * Pregnancy
  • * History of renal failure, or renal transplant
  • * Self-reported sleep duration less than 5 hours per night on weeknights (work nights)
  • * Other sleep disorders
  • * Use of supplemental oxygen during wakefulness or sleep
  • * Self-reported illicit drug use or marijuana use more than once per week
  • * Unstable medical conditions: uncontrolled angina, uncontrolled hypertension, severe chronic obstructive pulmonary disease, active cancer, or unstable psychiatric disease
  • * Any underlying condition that, in the opinion of the lead investigator, prohibits participation in the study
  • * Development or adoption of any of the above exclusion criteria during the study period

Ages Eligible for Study

30 Years to 75 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Ohio State University,

Ulysses Magalang, MD, PRINCIPAL_INVESTIGATOR, Ohio State University

Study Record Dates

2032-03-01