Corticostriatal Contributions to Parkinson's Disease Cognitive Impairment

Description

The goal of this study is to learn more about the brain activity underlying Parkinson's disease cognitive impairment. The investigators will utilize neural recordings from corticostriatal structures performed during deep brain stimulation surgery to measure neural activity underlying nonmotor symptoms of Parkinson's disease.

Conditions

Parkinson Disease

Study Overview

Study Details

Study overview

The goal of this study is to learn more about the brain activity underlying Parkinson's disease cognitive impairment. The investigators will utilize neural recordings from corticostriatal structures performed during deep brain stimulation surgery to measure neural activity underlying nonmotor symptoms of Parkinson's disease.

Corticostriatal Neurophysiology in Parkinson's Disease Cognitive Impairment

Corticostriatal Contributions to Parkinson's Disease Cognitive Impairment

Condition
Parkinson Disease
Intervention / Treatment

-

Contacts and Locations

Nashville

Vanderbilt University Medical Center, Nashville, Tennessee, United States, 37232

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Scheduled to undergo deep brain stimulation surgery under local anesthesia at Vanderbilt University Medical Center
  • * Planned clinical electrode trajectory that contacts caudate
  • * Age greater than or equal to 40
  • * Diagnosis of Parkinson's disease
  • * Able to participate in intraoperative testing
  • * English speaking
  • * Age less than 40
  • * Not able to participate in intraoperative testing (for example unable to comprehend instructions or follow directions)
  • * Movement disorder other than Parkinson's disease

Ages Eligible for Study

40 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Vanderbilt University Medical Center,

Sarah Bick, MD, PRINCIPAL_INVESTIGATOR, Vanderbilt University Medical Center

Study Record Dates

2026-02