Identifying Modifiable PAtient Centered Therapeutics (IMPACT) Frailty

Description

Frailty, the decline in physical and cognitive reserves leading to vulnerability to stressors is increasingly being recognized as a public health concern. Although multiple measures exist that can identify frail patients, very little is known about how or when to intervene. Sarcopenia, or the degree of muscle wasting, is closely correlated to frailty and patient outcomes. This is a prospective cohort study of critically ill patients to identify modifiable risk factors of sarcopenia, as potential targets to reduce frailty.

Conditions

Frailty, Sarcopenia

Study Overview

Study Details

Study overview

Frailty, the decline in physical and cognitive reserves leading to vulnerability to stressors is increasingly being recognized as a public health concern. Although multiple measures exist that can identify frail patients, very little is known about how or when to intervene. Sarcopenia, or the degree of muscle wasting, is closely correlated to frailty and patient outcomes. This is a prospective cohort study of critically ill patients to identify modifiable risk factors of sarcopenia, as potential targets to reduce frailty.

Identifying Modifiable PAtient Centered Therapeutics Frailty: an Observational Cohort Study

Identifying Modifiable PAtient Centered Therapeutics (IMPACT) Frailty

Condition
Frailty
Intervention / Treatment

-

Contacts and Locations

Los Angeles

Ronald Reagan UCLA Medical Center, Department of Anesthesiology & Perioperative Medicine, Los Angeles, California, United States, 90095

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Adult patients admitted to the Surgical, Cardiothoracic or Neuro ICU
  • * ICU stay longer than 24 hours
  • * Patients with muscular or mitochondrial diseases affecting muscle quality or mass
  • * Preexisting paralysis
  • * Absence of lower limbs
  • * Ongoing discussions about goals of care
  • * Transfers from a skilled nursing facility
  • * Children under the age of 18

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of California, Los Angeles,

Cecilia Canales, MD, MPH, PRINCIPAL_INVESTIGATOR, UCLA Department of Anesthesiology and Perioperative Medicine

Study Record Dates

2026-07