Aberrant Synaptic Plasticity in Cocaine Use Disorder: A 11C-UCB-J PET Study

Description

The purpose of this research study is to measure synaptic density in the brain comparing individuals with cocaine use disorder to healthy controls.

Conditions

Cocaine Use Disorder, Healthy Controls

Talk to us

Study Overview

On this page

Study Details

Study overview

The purpose of this research study is to measure synaptic density in the brain comparing individuals with cocaine use disorder to healthy controls.

Aberrant Synaptic Plasticity in Cocaine Use Disorder: A 11C-UCB-J PET Study

Aberrant Synaptic Plasticity in Cocaine Use Disorder: A 11C-UCB-J PET Study

Condition
Cocaine Use Disorder
Intervention / Treatment

-

Contacts and Locations

New Haven

Connecticut Mental Health Center, New Haven, Connecticut, United States, 06519

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age 21-60 years
  • * Physically healthy by medical history, physical, neurological, ECG and laboratory examinations
  • * For females, a negative serum pregnancy test
  • * For CUD: DSM-5 criteria for Cocaine Use Disorder and positive urine toxicology showing recent use
  • * For HC: Negative urine toxicology
  • * DSM-5 criteria for other substance use disorders (e.g., alcohol, opiates, sedative hypnotics), except for nicotine
  • * A primary DSM-5 Axis I major psychiatric disorder (e.g., schizophrenia, bipolar disorder, major depression, etc.) as determined by the Structured Clinical Interview for DSM-5 (SCID-5)
  • * A history of significant and/or uncontrolled medical or neurological illness
  • * Current use of psychotropic and/or potentially psychoactive prescription medications
  • * Medical contraindications to MRI procedure

Ages Eligible for Study

21 Years to 60 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Yale University,

Gustavo Angarita, MD, PRINCIPAL_INVESTIGATOR, Yale University

Study Record Dates

2026-06