Time-Restricted Eating and Cancer: Clinical Outcomes, Mechanisms, and Moderators

Description

The purpose of this study is to test whether the timing of meals can improve treatment adverse events, influence tumor biology and alter a person's mood and behaviors.

Conditions

Colorectal Cancer, Breast Cancer

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Study Overview

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Study Details

Study overview

The purpose of this study is to test whether the timing of meals can improve treatment adverse events, influence tumor biology and alter a person's mood and behaviors.

Time-Restricted Eating and Cancer: Clinical Outcomes, Mechanisms, and Moderators

Time-Restricted Eating and Cancer: Clinical Outcomes, Mechanisms, and Moderators

Condition
Colorectal Cancer
Intervention / Treatment

-

Contacts and Locations

West Hollywood

Cedars-Sinai Medical Center, West Hollywood, California, United States, 90048

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Any sex/gender of any ethnic/racial background
  • * Age greater than or equal to 18 years
  • * Histologically confirmed rectal cancer stage II, III, or IV (if curative) per AJCC criteria
  • * Histologically confirmed breast cancer stage II, III, or IV (only if definitive intent) per AJCC criteria
  • * BMI 18.5 kg/m2 or greater
  • * Will receive total neoadjuvant therapy (TNT)
  • * Willing and able to adhere to the assessments, visit schedules, prohibitions, and restrictions
  • * History of cytotoxic chemotherapy less than or equal to 12 months prior to rectal or breast cancer diagnosis
  • * Allergic reaction to any of the treatment agents
  • * Any prior pelvic radiotherapy
  • * Currently active second malignancy other than non-melanoma skin cancers or cervical carcinoma in situ
  • * History of GI perforation ≤12 months prior to enrollment
  • * History of predisposing colonic or small bowel disorders with severe or rapidly worsening symptoms (not related to current cancer symptoms)
  • * Receiving any parenteral nutrition or enteral (tube) feeding or using similar nutritional supplement during the study period
  • * History of uncontrolled CHF defined as NYHA Class III or greater
  • * Pre-existing grade ≥3 neuropathy
  • * Currently participating in or has participated in a study of an investigational agent or investigational device ≤4 weeks of the first dose of treatment
  • * Pregnant or breastfeeding
  • * Currently perform overnight shift work more than one day/week on average
  • * Strictly adhering to a \<10-hour eating window on most days
  • * Known psychiatric or substance abuse disorders that would interfere with adhering to the requirements of the trial

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Cedars-Sinai Medical Center,

Study Record Dates

2026-12-31