Improving Cognitive Function Through High-intensity Interval Training in Breast Cancer Patients Undergoing Chemotherapy

Eligibility Criteria

• * Written informed consent prior to any study-related procedures
• * Women newly diagnosed (Stage I-III) breast cancer.
• * Over the age of 18 years; children under the age of 18 will be excluded due to rarity of disease
• * The effects of exercise on the developing fetus are unknown. For this reason, women of child-bearing potential must agree to undergo a pregnancy test and to use adequate contraception (hormonal or barrier method of birth control or abstinence) prior to study entry and for six months following duration of study participation. Should a woman become pregnant or suspect that she is pregnant while participating on the trial, she should inform her treating physician immediately.
• * Will receive (neo)adjuvant chemotherapy
• * Speak English
• * Able to provide physician clearance to participate in the exercise program
• * Able to initiate a supervised exercise program (free from any cardiovascular, respiratory or musculoskeletal disease or joint problems that preclude moderate physical activity)
• * Have not experienced a weight reduction ≥10% within the past 6 months
• * Currently participate in less than 60 minutes of structured exercise/week
• * Does not smoke (no smoking during previous 12 months)
• * Willing to travel to DFCI for assessments (54 visits total for those who elect the exercise group with on campus training session, 6 visits for those that elect the exercise at home option, 6 visits for those assigned to the control group)
• * Ability to understand and the willingness to sign a written informed consent document.
• * Patients should not have any uncontrolled illness including ongoing or active infection, uncontrolled diabetes, hypertension or thyroid disease
• * Patients with other active malignancies are ineligible for this study.
• * Patients with metastatic disease
• * Medical history of coronary heart or artery disease, chronic or acute congestive heart failure or history of systolic or diastolic insufficiencies
• * Participates in more than 60 minutes of structured exercise/week
• * Orthopedic or other restrictions or contraindications to high-intensity (cycling) exercise
• * Have a pacemaker or any implantable device that are not MRI safe; the BWH/DFCI Standard MRI screening form
• * Is unable to travel to DFCI
• * Patients who are pregnant
• * Patients with claustrophobia
• * Subjects, who in the opinion of the investigator, may not be able to comply with the safety monitoring requirements of the study.