Apraxia in Parkinson's Disease Patients With Deep Brain Stimulation

Description

Deep brain stimulation (DBS) of the subthalamic nucleus or globus pallidus internus can improve motor symptoms Parkinson's disease (PD). However, it is not known whether DBS can help reduce the signs and symptoms of the limb-kinetic, ideomotor or ideational apraxia associated with PD or if apraxia can exist as a stimulation induced side effect from DBS therapy. In this study, we look to conduct a pilot study to examine the feasibility of characterizing the prevalence of apraxia in PD patients with chronic, stable DBS.

Conditions

Deep Brain Stimulation, Parkinson Disease, Apraxia, Motor

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Study Overview

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Study Details

Study overview

Deep brain stimulation (DBS) of the subthalamic nucleus or globus pallidus internus can improve motor symptoms Parkinson's disease (PD). However, it is not known whether DBS can help reduce the signs and symptoms of the limb-kinetic, ideomotor or ideational apraxia associated with PD or if apraxia can exist as a stimulation induced side effect from DBS therapy. In this study, we look to conduct a pilot study to examine the feasibility of characterizing the prevalence of apraxia in PD patients with chronic, stable DBS.

Apraxia in Parkinson's Disease Patients With Deep Brain Stimulation

Apraxia in Parkinson's Disease Patients With Deep Brain Stimulation

Condition
Deep Brain Stimulation
Intervention / Treatment

-

Contacts and Locations

Gainesville

UF Health at the University of Florida, Gainesville, Florida, United States, 32608

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Patients with PD as defined by the UK Brain Bank Criteria
  • 2. Male or female, ages 18 to 80 years old
  • 3. Chronically implanted DBS of either the STN or GPi for a minimum of 6 months
  • 1. Other neurological diagnoses (e.g. Alzheimer's disease, atypical parkinsonism, stroke)
  • 2. History of previous neurosurgical intervention that was not DBS
  • 3. Patients with DBS of targets other than the STN or GPi, or leads in both targets
  • 4. Patients in whom there is poor manual dexterity for a reason other than PD (e.g. orthopedic injury, amputation)
  • 5. Patients with a diagnosis of PD dementia

Ages Eligible for Study

18 Years to 80 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Florida,

Bhavana Patel, DO, PRINCIPAL_INVESTIGATOR, University of Florida

Study Record Dates

2025-06-30