RECRUITING

Imaging of T-cell Activation With [18F]F-AraG in Advanced Non Small Cell Lung Cancer

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This is a pilot study using \[18F\]F AraG PET imaging to evaluate the immunological response to checkpoint inhibitor therapy (CkIT) in patients with advanced NSCLC tumors at multiple study sites. The main objectives of the study are to quantify the change in \[18F\]F AraG PET signal before and after CkIT therapy, and to correlate this change in \[18F\]F AraG PET signal with a radiographic response.

Official Title

Imaging of T-cell Activation With [18F]F-AraG in Advanced Non Small Cell Lung Cancer (NSCLC) Patients Undergoing PD-1/PD-L1 Directed Therapy

Quick Facts

Study Start:2021-04-15
Study Completion:2024-10-15
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04726215

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. 1. Patients with a histologically confirmed NSCLC and planned to undergo immunotherapy as monotherapy or as combination therapy with concurrent as treatment for advanced/metastatic disease.
  2. 2. RECIST measurable disease.
  3. 3. ECOG performance status of 0, 1 or 2.
  4. 4. Life expectancy \>/= 6 months at enrollment.
  1. 1. Serious comorbidities that in the opinion of the investigator/sponsor could compromise protocol objectives.
  2. 2. Pregnant women or nursing mothers.
  3. 3. Patients with severe claustrophobia.

Contacts and Locations

Study Contact

SAMUEL QUEZADA
CONTACT
6507991589
squezada@cellsighttech.com

Principal Investigator

Deepak Behera, MD
PRINCIPAL_INVESTIGATOR
CellSight Technologies, Inc.

Study Locations (Sites)

Palo Alto Veterans Institute of Research
Palo Alto, California, 94304
United States
Sutter Cancer Center
Sacramento, California, 95816
United States
Stony Brook University
Stony Brook, New York, 11794
United States

Collaborators and Investigators

Sponsor: CellSight Technologies, Inc.

  • Deepak Behera, MD, PRINCIPAL_INVESTIGATOR, CellSight Technologies, Inc.

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-04-15
Study Completion Date2024-10-15

Study Record Updates

Study Start Date2021-04-15
Study Completion Date2024-10-15

Terms related to this study

Additional Relevant MeSH Terms

  • Non Small Cell Lung Cancer