Motor Cortical Neuromodulation in Women With Interstitial Cystitis/Bladder Pain Syndrome

Description

Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) is a common, chronic, and debilitating condition in women. Preliminary evidence suggests that IC/BPS pain can be reduced applying non-invasive repetitive transcranial magnetic stimulation (rTMS) to areas of the brain that regulate pelvic floor muscle activity. However, prior studies have examined rTMS in a very limited sample and have not examined changes in brain or pelvic floor muscle activity to determine the mechanism of rTMS for IC/BPS. This study is designed to directly address these limitations.

Conditions

Interstitial Cystitis, Bladder Pain Syndrome

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Study Overview

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Study Details

Study overview

Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) is a common, chronic, and debilitating condition in women. Preliminary evidence suggests that IC/BPS pain can be reduced applying non-invasive repetitive transcranial magnetic stimulation (rTMS) to areas of the brain that regulate pelvic floor muscle activity. However, prior studies have examined rTMS in a very limited sample and have not examined changes in brain or pelvic floor muscle activity to determine the mechanism of rTMS for IC/BPS. This study is designed to directly address these limitations.

Motor Cortical Neuromodulation in Women With Interstitial Cystitis/Bladder Pain Syndrome: Reducing Pain by Improving Brain and Muscle Activity

Motor Cortical Neuromodulation in Women With Interstitial Cystitis/Bladder Pain Syndrome

Condition
Interstitial Cystitis
Intervention / Treatment

-

Contacts and Locations

Los Angeles

University of Southern California, Los Angeles, California, United States, 90049

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Be at least 18 years old.
  • 2. Be female.
  • 3. Have a diagnosis of IC/BPS by the referring physician, with urologic symptoms present a majority of the time during the most recent 3 months
  • 4. Screen within standard limits for pelvic pain
  • 1. Symptomatic urethral stricture
  • 2. On-going neurological conditions affecting the bladder or bowel
  • 3. Active auto-immune or infectious disorders
  • 4. History of cystitis caused by tuberculosis or radiation or chemotherapies
  • 5. History of non-dermatologic cancer
  • 6. Current major psychiatric disorders
  • 7. Severe cardiac, pulmonary, renal, or hepatic disease
  • 8. Conditions or the use of medical devices that are contraindications for either fMRI or rTMS procedures, including pregnancy, seizure disorders, or chronic headaches

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Southern California,

Jason J Kutch, PhD, PRINCIPAL_INVESTIGATOR, University of Southern California

Study Record Dates

2025-08-15