Real-Time Levodopa Level Monitoring in Parkinson Disease

Description

This project aims to develop a minimally invasive sensor device to monitor levodopa levels in real time. We will test the accuracy, tolerability, and safety of this device in people with Parkinson disease.

Conditions

Parkinson Disease

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Study Overview

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Study Details

Study overview

This project aims to develop a minimally invasive sensor device to monitor levodopa levels in real time. We will test the accuracy, tolerability, and safety of this device in people with Parkinson disease.

Real-Time Levodopa Monitoring for Improved Management of Parkinson Disease

Real-Time Levodopa Level Monitoring in Parkinson Disease

Condition
Parkinson Disease
Intervention / Treatment

-

Contacts and Locations

San Diego

University of California San DIego, San Diego, California, United States, 92093

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Participants must meet the Movement Disorders Society (MDS) diagnostic criteria for clinically established Parkinson disease.
  • 2. Able to provide signed informed consent (in English or Spanish)
  • 3. Mild, moderate, or severe Parkinson disease, able to ambulate (Hoehn and Yahr stages I-IV)
  • 4. Taking instant release oral carbidopa/levodopa therapy
  • 5. Either not taking, or on stable doses of any of the following antiparkinsonian medications: dopamine agonists, monoamine oxidase B (MAO-B) inhibitors or catecholamine O-methyl transferase (COMT) inhibitors
  • 1. Other neurological conditions including but not limited to stroke, dementia (including Parkinson disease dementia), or traumatic brain injury
  • 2. Co-existent major psychiatric disease
  • 3. Uncontrolled, active medical conditions (e.g., heart, kidney, or liver failure, diabetes, etc.)
  • 4. Status post deep brain stimulation (DBS) device placement
  • 5. Any other condition, that in the opinion of the investigators, would place the participant at risk.

Ages Eligible for Study

40 Years to 85 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of California, San Diego,

Irene Litvan, MD, PRINCIPAL_INVESTIGATOR, UCSD

Study Record Dates

2028-02