Promoting HIV Risk Reduction Among People Who Inject Drugs: A Stepped Care Approach Using Contingency Management With PrEP Adherence and Support Services

Description

The proposed study will be a 24-week intervention with a 12-month follow-up period to evaluate the impact of contingency management with stepped care to pre-exposure prophylaxis (PrEP) adherence and support services (CoMPASS) to promote HIV prevention among individuals with opioid use disorder who have injected drugs in their lifetime. In parallel, the investigators will conduct an implementation focused process evaluation to inform real-world implementation of CoMPASS. .

Conditions

Opioid-use Disorder, HIV Prevention Program

Talk to us

Study Overview

On this page

Study Details

Study overview

The proposed study will be a 24-week intervention with a 12-month follow-up period to evaluate the impact of contingency management with stepped care to pre-exposure prophylaxis (PrEP) adherence and support services (CoMPASS) to promote HIV prevention among individuals with opioid use disorder who have injected drugs in their lifetime. In parallel, the investigators will conduct an implementation focused process evaluation to inform real-world implementation of CoMPASS. .

Promoting HIV Risk Reduction Among People Who Inject Drugs: A Stepped Care Approach Using Contingency Management With PrEP Adherence and Support Services

Promoting HIV Risk Reduction Among People Who Inject Drugs: A Stepped Care Approach Using Contingency Management With PrEP Adherence and Support Services

Condition
Opioid-use Disorder
Intervention / Treatment

-

Contacts and Locations

Bridgeport

Recovery Network of Programs, Inc, Bridgeport, Connecticut, United States, 06484

Bridgeport

Liberations Program, Inc, Bridgeport, Connecticut, United States, 06604

Danbury

Apex Community Care. Inc., Danbury, Connecticut, United States, 06810

New Haven

Greater Hartford Harm Reduction Coalition- SWAN, New Haven, Connecticut, United States, 06511

New Haven

APT, New Haven, Connecticut, United States, 06519

Fall River

Stanley Street Treatment and Resource Center, Fall River, Massachusetts, United States, 02720

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Receive or willing to receive care at one of the participating study sites
  • 2. Have a recent negative HIV test with no concern for acute HIV
  • 3. Report injection drug use in their lifetime
  • 4. Meet PrEP eligibility criteria by either a) sharing of injection or drug preparation equipment; b) sexual risk behaviors (i.e. condomless sex or STI) in the past 6 months
  • 5. Meet Diagnostic and Statistical Manual of Mental Disorders - 5th edition (DSM5) criteria for opioid use disorder
  • 6. Have a phone or use of a household member's phone
  • 7. Provide written informed consent
  • 1. Currently employed at one of the participating study sites
  • 2. Willing to complete a web-based survey
  • 1. Currently prescribed PrEP
  • 2. Self-report or urine test confirming pregnancy, breastfeeding, or trying to conceive
  • 3. Any plans that would preclude study completion (surgery, major medical treatment or conditions, incarceration, travel out of state or country.)
  • 4. Inability to provide at least one collateral contact for a friend or family member.
  • 5. Non-English speaking (for sites without Spanish-speaking staff)
  • 6. Have kidney disease (a contraindication to PrEP)
  • 1. Non-English speaking

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Yale University,

E. Jennifer Edelman, MD, MHS, PRINCIPAL_INVESTIGATOR, Yale University

Study Record Dates

2026-06-30