Food and Circadian Timing

Description

The goals of this study are to uncover the influence of diet on the human circadian timing system. The protocol is a 46-day (28 outpatient days, 18 inpatient days over two 9 day visits) randomized cross-over study designed to elucidate the speed of entrainment in response to a high-fat diet.

Conditions

Diet, High-Fat, Circadian Rhythm

Talk to us

Study Overview

On this page

Study Details

Study overview

The goals of this study are to uncover the influence of diet on the human circadian timing system. The protocol is a 46-day (28 outpatient days, 18 inpatient days over two 9 day visits) randomized cross-over study designed to elucidate the speed of entrainment in response to a high-fat diet.

Uncovering the Impact of Diet on the Human Circadian Timing System

Food and Circadian Timing

Condition
Diet, High-Fat
Intervention / Treatment

-

Contacts and Locations

Portland

Oregon Health & Science University, Portland, Oregon, United States, 97239

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Healthy, lean men and women
  • * Major dietary restrictions (such as entirely dairy-free and/or meat-free diets)
  • * A body mass index (BMI) of 18.5\< \[BMI\] \< 24.9 kg/m\^2 and a waist circumference \<94/80cm
  • * Currently psychiatrically/psychologically unsuitable for participation
  • * Drug/alcohol use, including smoking
  • * Medication/drug use, including prescribed and over-the-counter medications
  • * History of working irregular day and night hours, regular night work, or rotating shift work for the 1 year prior to the study.
  • * Traveled across more than 1 time zone during the 3 months prior to the study
  • * Currently consuming a habitual high-fat diet
  • * Chronobiologic and sleep disorders
  • * Diseases of the Cardiovascular System
  • * Metabolic Syndrome; Two or more of these factors will be excluded from the study:
  • 1. HDL cholesterol of less than 40 mg/dL in men or less than 50 mg/dL in women;
  • 2. systolic blood pressure\>135 mmHg or diastolic blood pressure\>85 mmHg;
  • 3. Fasting blood glucose ≥ 100 mg/dL;
  • 4. Triglycerides ≥ 150 mg/dL.
  • * Pre-Diabetes/Diabetes
  • * Hypertension
  • * Disorders of the Respiratory System
  • * Disorders of the Kidney and Urinary Tract
  • * Infectious Diseases
  • * Disorders of the Gastrointestinal System
  • * Disorders of the Immune System
  • * Disorders of the Hematopoietic System
  • * Neoplastic Diseases
  • * Endocrine and Metabolic Diseases
  • * Neurologic Disorders
  • * Subjects must not be currently participating in another research study that would influence their safe participation in our study

Ages Eligible for Study

18 Years to 40 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Oregon Health and Science University,

Andrew McHill, PhD, PRINCIPAL_INVESTIGATOR, Oregon Health and Science University

Study Record Dates

2026-03-31