RECRUITING

Developing New Educational Materials About Genetic Testing for a Diverse Group of Cancer Patients

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Genetic testing is a type of test that detects changes to the genes-the DNA instructions that are passed on from the mother and father. The results of a genetic test can confirm whether the participant has a genetic disorder, which is a disease caused in whole or in part by changes to the genes. Genetic testing can also help determine a person's chance of getting or passing on a genetic disorder. Genetic tests use a sample of blood, hair, skin, or other tissue, and they can look at one gene or multiple genes at the same time. Genetic testing may change the options for treating people with certain types of cancer. For example, some medications are more helpful for the treatment of cancer in people with certain gene changes (mutations). The researchers are doing this study to develop new educational materials about genetic testing for people who speak different languages and have diverse cultural and educational backgrounds. During the study, the staff will interview participants with diverse cultural and educational backgrounds and ask them to review a sample of the educational materials that have been developed so far. Participants will give their opinions on these materials, and the researchers will use participants' feedback to improve the materials.

Official Title

IMAGINE: IMproving Access to Genetic INformation for Everyone - a Prospective Trial of a Linguistically and Culturally Appropriate Mainstreaming Model for Hereditary Cancer Multigene Panel Testing Among Diverse Cancer Patients

Quick Facts

Study Start:2021-11-16
Study Completion:2026-08-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04751435

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Age ≥ 18 years as per self-report
  2. * Current or previous diagnosis of breast, ovarian, pancreatic, or prostate cancer as per self-report
  3. * Self-identification as Black, Latino, and/or neither Black nor Latino (i.e.,non-Latino, Non black)
  4. * Fluency in English, Haitian Creole, or Spanish as per self-report (for Spanish, we will attempt to recruit a cohort representing a variety of regions where Spanish is spoken, as informed by current data from participating sites, to achieve neutrality in the language) Fluency is defined as an answer of "well" or "very well" on the screening questions for spoken and reading ability.
  5. * Age ≥ 18 years as per the medical record
  6. * Current or previous diagnosis of breast, colorectal, ovarian, pancreatic, or prostate cancer meeting at least one of the applicable criteria for the cancer type as per the medical record and/or clinician referral:
  7. * Breast cancer criteria:
  8. * any diagnosis age 65 or younger;
  9. * diagnosis of triple negative breast cancer at any age;
  10. * multiple primary breast cancers at any age;
  11. * under consideration for PARP therapy;
  12. * any family history (1st, 2nd, or 3rd degree relatives) of ovarian or pancreas cancer, or 1 relative with breast cancer who meets the above criteria, or 2 relatives with breast cancer at any age; or clinician discretion)
  13. * Colorectal cancer criteria:
  14. * any diagnosis age 50 and below;
  15. * mismatch repair deficient colorectal cancer;
  16. * colorectal cancer at any age with an additional Lynch syndromerelated primary cancer at any age;
  17. * colorectal cancer at any age with a 1st or 2nd degree relative with colorectal cancer at/before age 50;
  18. * colorectal cancer at any age with 2 or more 1st or 2nd degree relatives with a Lynch syndrome-related cancer at any age
  19. * Ovarian cancer criteria:
  20. * Pancreatic cancer criteria:
  21. * Prostate cancer criteria:
  22. * castrate-resistant, metastatic prostate cancer;
  23. * high-risk prostate cancer (pending pathology definition)
  24. * Fluency in English, Haitian Creole, or Spanish as per self-report. Fluency is defined as an answer of "well" or "very well" on the screening questions for spoken and reading ability
  25. * No prior cancer genetic counseling or germline testing for cancer risk as per selfreport
  1. * Individuals of impaired decision-making capacity as per a clinician's or consenting professional's judgment.
  2. * Subjects who indicate level of fluency as "not at all" or "not well".

Contacts and Locations

Study Contact

Jada Hamilton, PhD, MPH
CONTACT
646-888-0049
hamiltoj@mskcc.org
Jennifer Hay, PhD
CONTACT
646-888-0039

Principal Investigator

Jada Hamilton, PhD, MPH
PRINCIPAL_INVESTIGATOR
Memorial Sloan Kettering Cancer Center

Study Locations (Sites)

Kings County Hopsital Center
Brooklyn, New York, 11203
United States
Queens Cancer Center of Queens Hospital
Jamaica, New York, 11432
United States
Memorial Sloan Kettering at Ralph Lauren Center (Limited Protocol Activities)
New York, New York, 10035
United States

Collaborators and Investigators

Sponsor: Memorial Sloan Kettering Cancer Center

  • Jada Hamilton, PhD, MPH, PRINCIPAL_INVESTIGATOR, Memorial Sloan Kettering Cancer Center

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-11-16
Study Completion Date2026-08-31

Study Record Updates

Study Start Date2021-11-16
Study Completion Date2026-08-31

Terms related to this study

Keywords Provided by Researchers

  • Educational Materials
  • Genetic Testing
  • Hereditary Cancer
  • Diverse Cancer Patients
  • 20-458

Additional Relevant MeSH Terms

  • Educational Materials for Genetic Testing
  • Breast Cancer
  • Ovarian Cancer
  • Prostate Cancer
  • Pancreatic Cancer