RECRUITING

Nutritional Stimulation of Muscle Protein Synthesis and Metabolic Rate After Bariatric Surgery

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Bariatric surgery is an effective treatment for severe obesity but results in loss of muscle mass. The investigators will test the hypothesis that consumption of an Essential Amino Acid-based nutritional formulation will maintain muscle mass while stimulating fat loss after bariatric surgery.

Official Title

Nutritional Stimulation of Muscle Protein Synthesis and Metabolic Rate After Bariatric Surgery

Quick Facts

Study Start:2021-03-09
Study Completion:2024-02-28
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04751916

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 60 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * A determination to proceed with bariatric surgery
  2. * Roux-en-Y gastric bypass or sleeve gastrectomy
  3. * Absence of any exclusion
  1. * Contraindications to Magnetic Resonance Spectroscopy/Magnetic Resonance Imaging
  2. * greater than 450 pounds (scan table limit)
  3. * Renal Failure requiring dialysis
  4. * Liver disease as indicated by bilirubin \>2 or Fibrosis-4 score ≥6
  5. * Cardiac disease such as Left Ventricular Assist Device requirement
  6. * Uncontrolled diabetes as indicated by Hemoglobin A1c \>8
  7. * Positive pregnancy test (for participants in whom pregnancy is possible)
  8. * Any other exclusion per indication of clinical surgeon
  9. * Refusal to consume study formula

Contacts and Locations

Study Contact

Lauren P Martin, MS RD LD
CONTACT
(971)288-8487
marlaure@ohsu.edu
Sarah D Livingston
CONTACT
(503)494-1322
livingss@ohsu.edu

Principal Investigator

Nancy Puzziferri, MD MSCS
PRINCIPAL_INVESTIGATOR
Oregon Health and Science University

Study Locations (Sites)

Oregon Health and Science University
Portland, Oregon, 97239
United States

Collaborators and Investigators

Sponsor: Oregon Health and Science University

  • Nancy Puzziferri, MD MSCS, PRINCIPAL_INVESTIGATOR, Oregon Health and Science University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-03-09
Study Completion Date2024-02-28

Study Record Updates

Study Start Date2021-03-09
Study Completion Date2024-02-28

Terms related to this study

Keywords Provided by Researchers

  • bariatric surgery
  • muscle synthesis
  • weight loss
  • essential amino acids
  • protein supplementation
  • total energy expenditure

Additional Relevant MeSH Terms

  • Weight Loss