Nutritional Stimulation of Muscle Protein Synthesis and Metabolic Rate After Bariatric Surgery

Description

Bariatric surgery is an effective treatment for severe obesity but results in loss of muscle mass. The investigators will test the hypothesis that consumption of an Essential Amino Acid-based nutritional formulation will maintain muscle mass while stimulating fat loss after bariatric surgery.

Conditions

Weight Loss

Study Overview

Study Details

Study overview

Bariatric surgery is an effective treatment for severe obesity but results in loss of muscle mass. The investigators will test the hypothesis that consumption of an Essential Amino Acid-based nutritional formulation will maintain muscle mass while stimulating fat loss after bariatric surgery.

Nutritional Stimulation of Muscle Protein Synthesis and Metabolic Rate After Bariatric Surgery

Nutritional Stimulation of Muscle Protein Synthesis and Metabolic Rate After Bariatric Surgery

Condition
Weight Loss
Intervention / Treatment

-

Contacts and Locations

Portland

Oregon Health and Science University, Portland, Oregon, United States, 97239

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * A determination to proceed with bariatric surgery
  • * Roux-en-Y gastric bypass or sleeve gastrectomy
  • * Absence of any exclusion
  • * Contraindications to Magnetic Resonance Spectroscopy/Magnetic Resonance Imaging
  • * greater than 450 pounds (scan table limit)
  • * Renal Failure requiring dialysis
  • * Liver disease as indicated by bilirubin \>2 or Fibrosis-4 score ≥6
  • * Cardiac disease such as Left Ventricular Assist Device requirement
  • * Uncontrolled diabetes as indicated by Hemoglobin A1c \>8
  • * Positive pregnancy test (for participants in whom pregnancy is possible)
  • * Any other exclusion per indication of clinical surgeon
  • * Refusal to consume study formula

Ages Eligible for Study

18 Years to 60 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Oregon Health and Science University,

Nancy Puzziferri, MD MSCS, PRINCIPAL_INVESTIGATOR, Oregon Health and Science University

Study Record Dates

2024-02-28