RECRUITING

Characterization of Biliary Cell-derived Organoids From Bile of PSC and Non-PSC Patients

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this research is to create a collection of bile, bile duct brushings and medical information from people with Primary Sclerosing Cholangitis (PSC) and controls to learn more about changes that occur in the liver.

Official Title

Characterization of Biliary Cell-derived Organoids From Bile of PSC and Non-PSC Patients

Quick Facts

Study Start:2021-03-08
Study Completion:2025-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04753996

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 85 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Patients diagnosed with PSC between the age of 18 and 85.
  2. * The diagnosis of PSC will be based on standard PSC criteria including clinical and biochemical evidence of chronic cholestasis of at least six months duration, positive cholangiographic findings and compatible liver biopsies if available.
  3. * Women with PSC of childbearing potential and pregnant women will be offered enrollment because there is no risk to an unborn child in this investigation. Patients with PSC and Cholangiocarcinoma will be included.
  1. * Patients unable to provide inform consent.
  2. * Prisoners and institutionalized individuals.
  3. * PSC with orthotopic liver transplantation
  4. * History of Roux En Y procedure

Contacts and Locations

Study Contact

Erik Schlicht, CCRP
CONTACT
(507) 284-4212
schlicht.erik@mayo.edu
Jackie Bianchi
CONTACT
(507) 266-0346
bianchi.jackie@mayo.edu

Principal Investigator

Konstantinos Lazaridis, MD
PRINCIPAL_INVESTIGATOR
Mayo Clinic

Study Locations (Sites)

Mayo Clinic in Rochester
Rochester, Minnesota, 55905
United States

Collaborators and Investigators

Sponsor: Mayo Clinic

  • Konstantinos Lazaridis, MD, PRINCIPAL_INVESTIGATOR, Mayo Clinic

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-03-08
Study Completion Date2025-01

Study Record Updates

Study Start Date2021-03-08
Study Completion Date2025-01

Terms related to this study

Additional Relevant MeSH Terms

  • Primary Sclerosing Cholangitis
  • PSC
  • Cholangiocarcinoma