Characterization of Biliary Cell-derived Organoids From Bile of PSC and Non-PSC Patients

Description

The purpose of this research is to create a collection of bile, bile duct brushings and medical information from people with Primary Sclerosing Cholangitis (PSC) and controls to learn more about changes that occur in the liver.

Conditions

Primary Sclerosing Cholangitis, PSC, Cholangiocarcinoma

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Study Overview

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Study Details

Study overview

The purpose of this research is to create a collection of bile, bile duct brushings and medical information from people with Primary Sclerosing Cholangitis (PSC) and controls to learn more about changes that occur in the liver.

Characterization of Biliary Cell-derived Organoids From Bile of PSC and Non-PSC Patients

Characterization of Biliary Cell-derived Organoids From Bile of PSC and Non-PSC Patients

Condition
Primary Sclerosing Cholangitis
Intervention / Treatment

-

Contacts and Locations

Rochester

Mayo Clinic in Rochester, Rochester, Minnesota, United States, 55905

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Patients diagnosed with PSC between the age of 18 and 85.
  • * The diagnosis of PSC will be based on standard PSC criteria including clinical and biochemical evidence of chronic cholestasis of at least six months duration, positive cholangiographic findings and compatible liver biopsies if available.
  • * Women with PSC of childbearing potential and pregnant women will be offered enrollment because there is no risk to an unborn child in this investigation. Patients with PSC and Cholangiocarcinoma will be included.
  • * Patients unable to provide inform consent.
  • * Prisoners and institutionalized individuals.
  • * PSC with orthotopic liver transplantation
  • * History of Roux En Y procedure

Ages Eligible for Study

18 Years to 85 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Mayo Clinic,

Konstantinos Lazaridis, MD, PRINCIPAL_INVESTIGATOR, Mayo Clinic

Study Record Dates

2025-01