Transfusion Requirements in Younger Patients Undergoing Cardiac Surgery

Description

TRICS-IV is an international, multi-centre, open-label randomized controlled trial of two commonly used transfusion strategies in moderate to high risk patients who are 65 years of age or younger undergoing cardiac surgery on cardiopulmonary bypass, using a superiority trial design.

Conditions

Disorder, Heart, Postoperative, Cardiac Surgery

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Study Overview

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Study Details

Study overview

TRICS-IV is an international, multi-centre, open-label randomized controlled trial of two commonly used transfusion strategies in moderate to high risk patients who are 65 years of age or younger undergoing cardiac surgery on cardiopulmonary bypass, using a superiority trial design.

An International, Multi-centre, Randomized Controlled Trial to Assess Transfusion Thresholds in Younger Patients Undergoing Cardiac Surgery

Transfusion Requirements in Younger Patients Undergoing Cardiac Surgery

Condition
Disorder
Intervention / Treatment

-

Contacts and Locations

Portland

Maine Medical Center, Portland, Maine, United States, 04102

Camden

The Cooper Health System, Camden, New Jersey, United States, 08103

New York

Columbia University, New York, New York, United States, 10032

Philadelphia

Thomas Jefferson University, Philadelphia, Pennsylvania, United States, 19107

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. ≥18 and ≤65 years of age
  • 2. Planned cardiac surgery using cardiopulmonary bypass
  • 3. Informed consent obtained
  • 4. Preoperative European System for Cardiac Operative Risk Evaluation (EuroSCORE I) of 6 or more
  • 1. Patients who refuse participation
  • 2. Patients who are unable to receive or who refuse blood products
  • 3. Patients who are involved in a preoperative autologous pre-donation program
  • 4. Patients who are having a heart transplant or having surgery solely for an insertion of a ventricular assist device
  • 5. Pregnancy or lactation (a negative pregnancy test must be obtained prior to randomization for women of childbearing potential)

Ages Eligible for Study

18 Years to 65 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Unity Health Toronto,

David Mazer, MD, PRINCIPAL_INVESTIGATOR, Unity Health Toronto

Nadine Shehata, MD, PRINCIPAL_INVESTIGATOR, MOUNT SINAI HOSPITAL

Study Record Dates

2026-06