RECRUITING

Elucidating the Temporality of Structural and Functional Connectivity Changes in Essential Tremor After Successful Deep Brain Stimulation to the Dentato-rubro-thalamic Tract

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Conditions

Essential Tremordeep brain stimulation

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to elucidate the structural connectivity of the dentato-rubro-thalamic tract (DRTt) and to detect functional network changes due to DRTt stimulation

Official Title

Elucidating the Temporality of Structural and Functional Connectivity Changes in Essential Tremor After Successful Deep Brain Stimulation to the Dentato-rubro-thalamic Tract

Quick Facts

Study Start:2021-12-04
Study Completion:2026-08-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04758624

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 85 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * the diagnosis of Essential Tremor, made by a movement disorder neurologist, where tremor is not secondary to any disease process or traumatic insult
  2. * distal appendicular tremor, with minimal proximal component
  3. * tremor refractory to multiple medication regimens and/or where the medications cause intolerable side effects
  4. * tremor judged to be severely impacting their quality of life.
  1. * significant neurological disorder
  2. * significant dementia or neurocognitive limitations as assessed by neuropsychiatry (when necessary)
  3. * severe psychiatric illness with suicidal ideations
  4. * previous surgery to destroy the target region of the brain
  5. * surgical contraindications to DBS
  6. * current major medical problems that affect brain anatomy,neurochemistry, or function, e.g., liver insufficiency, kidney insufficiency, cardiovascular problems, systemic infections, cancer, hypothyroidism, auto-immune diseases, and any current of history of brain disorder (seizure disorder, stroke, dementia, meningitis, encephalitis, degenerative neurologic diseases and head injury with loss of consciousness for any period of time)
  7. * family history of hereditary neurologic disorder, besides essential tremors ET
  8. * floating metallic objects in the body
  9. * pregnancy
  10. * alcohol or substance abuse/dependence in the past 6 months.

Contacts and Locations

Study Contact

Robert Ritter III
CONTACT
713-500-8914
Robert.Ritter@uth.tmc.edu

Principal Investigator

Albert J Fenoy, MD
PRINCIPAL_INVESTIGATOR
The University of Texas Health Science Center, Houston

Study Locations (Sites)

The University of Texas Health Science Center at Houston
Houston, Texas, 77030
United States

Collaborators and Investigators

Sponsor: Northwell Health

  • Albert J Fenoy, MD, PRINCIPAL_INVESTIGATOR, The University of Texas Health Science Center, Houston

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-12-04
Study Completion Date2026-08-31

Study Record Updates

Study Start Date2021-12-04
Study Completion Date2026-08-31

Terms related to this study

Keywords Provided by Researchers

  • deep brain stimulation

Additional Relevant MeSH Terms

  • Essential Tremor