Diuretic Tuner Clinical Decision Support

Description

This purpose of this study is to determine the effectiveness of a mobile phone application in helping to control body swelling in patients with kidney problems. The application will help in the day to day adjustments in diuretic medication dosing. Participants in this study will have an application loaded on to their mobile phone by the study team and be taught how to use it over a 2 hour visit. Participants will need to check their blood pressure and weight daily and enter this information into the mobile phone application every day. Participants will need to follow daily instructions in their medication dosing provided by the application. There will be periodic blood testing. This will happen at 2 weeks, 90 days, and up to 4 other times if necessary. At the end of the study there is a 2 hour study visit during which participants will answer a survey. The total length of the study is 90 days.

Conditions

Edema, Hypervolemia, Chronic Kidney Diseases, Nephrotic Syndrome

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Study Overview

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Study Details

Study overview

This purpose of this study is to determine the effectiveness of a mobile phone application in helping to control body swelling in patients with kidney problems. The application will help in the day to day adjustments in diuretic medication dosing. Participants in this study will have an application loaded on to their mobile phone by the study team and be taught how to use it over a 2 hour visit. Participants will need to check their blood pressure and weight daily and enter this information into the mobile phone application every day. Participants will need to follow daily instructions in their medication dosing provided by the application. There will be periodic blood testing. This will happen at 2 weeks, 90 days, and up to 4 other times if necessary. At the end of the study there is a 2 hour study visit during which participants will answer a survey. The total length of the study is 90 days.

Diuretic Tuner Clinical Decision Support Mobile Device Application for Diuretic Titration in Hypervolemic States

Diuretic Tuner Clinical Decision Support

Condition
Edema
Intervention / Treatment

-

Contacts and Locations

Dallas

University of Texas Southwestern, Dallas, Texas, United States, 75390

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * The presence of nephrotic range proteinuria (\> 3 g/d proteinuria by 24hr urine protein, 24hr urine albumin, spot urine protein/creatinine ratio, or spot urine albumin/creatinine ratio) or stage 4 or 5 chronic kidney disease (estimated glomerular filtration rate \< 30 mL/min/1.73 m2 by Modification of Diet in Renal Disease equation) PLUS
  • * Clinical signs of hypervolemia present (lower extremity edema, ascites, or pleural effusions) with an estimated dry weight (defined as edema-free weight without orthostatic hypotension) 5 lbs less than enrollment body weight
  • * Weight \< 100 lbs or \> 300 lbs.
  • * Autonomic insufficiency resulting in orthostatic hypotension at screening
  • * Hypokalemia at enrollment (defined as serum potassium \< 3.5 mmol/L)
  • * Moderate to severe hyponatremia at enrollment (defined as serum sodium \< 130 mmol/L)
  • * Serum creatinine \> 6 mg/dL or \> 1.5 times baseline
  • * Patients who are unable or unwilling to measure their home blood pressures and weights
  • * Patients without a working phone number and smart phone device
  • * Expectation that the patient will require dialysis initiation within \< 3 months
  • * Expected lifespan of \< 6 months
  • * The presence of a medical condition that would interfere with effectively using the Diuretic Tuner (dementia, illiteracy, or blindness)
  • * Pregnant patients
  • * Prisoners

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Texas Southwestern Medical Center,

Study Record Dates

2026-08