Evaluate the Effect of Atorvastatin on Cerebrovascular Reactivity in Mild Cognitive Impairment (MCI)

Description

The purpose of this study is to evaluate the effect of atorvastatin on brain vessel reactivity and with it on blood flow in people with mild cognitive impairment.

Conditions

Mild Cognitive Impairment

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Study Overview

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Study Details

Study overview

The purpose of this study is to evaluate the effect of atorvastatin on brain vessel reactivity and with it on blood flow in people with mild cognitive impairment.

Targeting Cerebrovascular Reactivity for Precision Medicine: Pilot Trial of Atorvastatin

Evaluate the Effect of Atorvastatin on Cerebrovascular Reactivity in Mild Cognitive Impairment (MCI)

Condition
Mild Cognitive Impairment
Intervention / Treatment

-

Contacts and Locations

Baltimore

Johns Hopkins University, Bayview Medical Center, Baltimore, Maryland, United States, 21224

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Taking a statin currently or have taken a statin in the last 6 months.
  • * Contraindications to taking a statin.
  • * Transplant patient taking cyclosporine.
  • * Unable to undergo MRI procedures (such as having an implanted pacemaker or defibrillator or stimulator or having non MRI compatible metal).
  • * Diagnosis of dementia by history.
  • * Current diagnosis of substance abuse.
  • * History of stroke or myocardial infarction in past 6 months.
  • * History of HIV.

Ages Eligible for Study

60 Years to 95 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Johns Hopkins University,

Paul Rosenberg, MD, PRINCIPAL_INVESTIGATOR, Johns Hopkins University

Study Record Dates

2026-12-31