RECRUITING

Advanced Cardiac Imaging To Predict Embolic Stroke On Brain MRI: A Pilot Study

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Demonstrating the pathophysiological link between Left Atrial (LA) and Left Atrial Appendage (LAA) pathology and embolic strokes in non-Atrial Fibrillation (AF) individuals represents a major advance in stroke prevention strategies. Instead of relying on non-specific criteria for stroke risk assessment, the investigators propose to identify individuals with high-risk of embolic stroke using imaging criteria that reflect the underlying pathophysiology of embolic stroke of cardiac origin. the investigators can therefore lay the groundwork for future anticoagulation strategies for stroke prevention beyond AF.

Official Title

Advanced Cardiac Imaging To Predict Embolic Stroke On Brain MRI: A Pilot Study

Quick Facts

Study Start:2021-04-26
Study Completion:2025-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04769310

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 120 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Male or female patients
  2. * 18 Years and older
  3. * No history of atrial fibrillation
  4. * CHA2DS2VASC score ≥3
  5. * History pf type II diabetes
  6. * History of congestive heart failure or a history of transient ischemic attack (TIA)/stroke without an otherwise defined stroke etiology such as large vessel or small vessel disease
  1. * History of atrial fibrillation
  2. * Patients who had a clinically symptomatic acute stroke within the last 30-days
  3. * Any health-related gadolinium/MRI contraindication (including previous allergic reaction to Gadolinium, pacemakers, defibrillators, other devices/implants contraindicated for MRI)
  4. * Estimated glomerular filtration rate (eGFR) cutoff in patients with Chronic kidney disease (CKD) where gadolinium cannot be used equals an eGFR \<30 ml/min
  5. * Weighing \> 300 lbs (as CMR image quality decreases due to increased body mass index)
  6. * Current pregnancy or breastfeeding
  7. * Cognitive impairment preventing the patient from giving an informed consent

Contacts and Locations

Study Contact

Quintrele Jones, MPH
CONTACT
504-988-3063
qjones1@tulane.edu

Principal Investigator

Nassir Marrouche, MD
PRINCIPAL_INVESTIGATOR
Tulane School of Medicine

Study Locations (Sites)

Tulane University Medical Center
New Orleans, Louisiana, 70112
United States

Collaborators and Investigators

Sponsor: Tulane University

  • Nassir Marrouche, MD, PRINCIPAL_INVESTIGATOR, Tulane School of Medicine

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-04-26
Study Completion Date2025-01

Study Record Updates

Study Start Date2021-04-26
Study Completion Date2025-01

Terms related to this study

Keywords Provided by Researchers

  • Magnetic Resonance Imaging
  • Cardiac Magnetic Resonance Imaging
  • Brain infarcts
  • Left atrial
  • Left atrial appendage
  • Non invasive cardiac imaging

Additional Relevant MeSH Terms

  • Atrial Fibrillation
  • Stroke
  • Stroke, Cardiovascular
  • Vascular Cognitive Impairment
  • Strokes Thrombotic
  • Stroke, Ischemic