Advanced Cardiac Imaging To Predict Embolic Stroke On Brain MRI: A Pilot Study

Description

Demonstrating the pathophysiological link between Left Atrial (LA) and Left Atrial Appendage (LAA) pathology and embolic strokes in non-Atrial Fibrillation (AF) individuals represents a major advance in stroke prevention strategies. Instead of relying on non-specific criteria for stroke risk assessment, the investigators propose to identify individuals with high-risk of embolic stroke using imaging criteria that reflect the underlying pathophysiology of embolic stroke of cardiac origin. the investigators can therefore lay the groundwork for future anticoagulation strategies for stroke prevention beyond AF.

Conditions

Atrial Fibrillation, Stroke, Stroke, Cardiovascular, Vascular Cognitive Impairment, Strokes Thrombotic, Stroke, Ischemic

Talk to us

Study Overview

On this page

Study Details

Study overview

Demonstrating the pathophysiological link between Left Atrial (LA) and Left Atrial Appendage (LAA) pathology and embolic strokes in non-Atrial Fibrillation (AF) individuals represents a major advance in stroke prevention strategies. Instead of relying on non-specific criteria for stroke risk assessment, the investigators propose to identify individuals with high-risk of embolic stroke using imaging criteria that reflect the underlying pathophysiology of embolic stroke of cardiac origin. the investigators can therefore lay the groundwork for future anticoagulation strategies for stroke prevention beyond AF.

Advanced Cardiac Imaging To Predict Embolic Stroke On Brain MRI: A Pilot Study

Advanced Cardiac Imaging To Predict Embolic Stroke On Brain MRI: A Pilot Study

Condition
Atrial Fibrillation
Intervention / Treatment

-

Contacts and Locations

New Orleans

Tulane University Medical Center, New Orleans, Louisiana, United States, 70112

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Male or female patients
  • * 18 Years and older
  • * No history of atrial fibrillation
  • * CHA2DS2VASC score ≥3
  • * History pf type II diabetes
  • * History of congestive heart failure or a history of transient ischemic attack (TIA)/stroke without an otherwise defined stroke etiology such as large vessel or small vessel disease
  • * History of atrial fibrillation
  • * Patients who had a clinically symptomatic acute stroke within the last 30-days
  • * Any health-related gadolinium/MRI contraindication (including previous allergic reaction to Gadolinium, pacemakers, defibrillators, other devices/implants contraindicated for MRI)
  • * Estimated glomerular filtration rate (eGFR) cutoff in patients with Chronic kidney disease (CKD) where gadolinium cannot be used equals an eGFR \<30 ml/min
  • * Weighing \> 300 lbs (as CMR image quality decreases due to increased body mass index)
  • * Current pregnancy or breastfeeding
  • * Cognitive impairment preventing the patient from giving an informed consent

Ages Eligible for Study

18 Years to 120 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Tulane University,

Nassir Marrouche, MD, PRINCIPAL_INVESTIGATOR, Tulane School of Medicine

Study Record Dates

2025-01