Ketamine vs Lidocaine in Traumatic Rib Fractures

Description

Rib fractures continue to be a common occurrence in trauma patients of all ages. Traumatic rib fractures can cause severe pain in patients and lead to shallow breathing and further complications such as the need for mechanical ventilation, hospital or ventilator associated pneumonia, atelectasis, and acute respiratory distress syndrome. Effective multimodal pain management is needed to optimize a patient's respiratory status and can also play a role in early mobility, less pulmonary complications, shorter ICU and hospital length of stay, and decreased mortality. Current multimodal pain management options include opioids, muscle relaxants, gabapentin, acetaminophen, nonsteroidal anti-inflammatory drugs, and various regional/neuraxial anesthesia techniques. Both ketamine and lidocaine infusions for pain control have also been shown in studies to be safe and effective, with the benefit of minimizing the use of opioids. However, there have been very few studies that have used ketamine or lidocaine infusions for pain control specifically in patients with traumatic rib fractures. Therefore, the purpose of this study is to evaluate ketamine versus lidocaine infusions as an adjunctive therapy to reduce opioid consumption in the first 72 hours in patients with multiple traumatic rib fractures.

Conditions

Rib Fractures, Rib Fracture Multiple, Rib Trauma

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Study Overview

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Study Details

Study overview

Rib fractures continue to be a common occurrence in trauma patients of all ages. Traumatic rib fractures can cause severe pain in patients and lead to shallow breathing and further complications such as the need for mechanical ventilation, hospital or ventilator associated pneumonia, atelectasis, and acute respiratory distress syndrome. Effective multimodal pain management is needed to optimize a patient's respiratory status and can also play a role in early mobility, less pulmonary complications, shorter ICU and hospital length of stay, and decreased mortality. Current multimodal pain management options include opioids, muscle relaxants, gabapentin, acetaminophen, nonsteroidal anti-inflammatory drugs, and various regional/neuraxial anesthesia techniques. Both ketamine and lidocaine infusions for pain control have also been shown in studies to be safe and effective, with the benefit of minimizing the use of opioids. However, there have been very few studies that have used ketamine or lidocaine infusions for pain control specifically in patients with traumatic rib fractures. Therefore, the purpose of this study is to evaluate ketamine versus lidocaine infusions as an adjunctive therapy to reduce opioid consumption in the first 72 hours in patients with multiple traumatic rib fractures.

A Prospective, Randomized, Single-Blinded Trial of Ketamine Versus Lidocaine Infusions for Multimodal Pain Management in Traumatic Rib Fracture Patients

Ketamine vs Lidocaine in Traumatic Rib Fractures

Condition
Rib Fractures
Intervention / Treatment

-

Contacts and Locations

Grand Rapids

Spectrum Health Hospital, Grand Rapids, Michigan, United States, 49503

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Adults ≥ 18 years old
  • 2. ≥ 3 traumatic blunt rib fractures
  • 3. Enrollment within 16 hours of being admitted to the hospital
  • 4. Patients whom in the investigator's clinical judgement, would require escalated pain control regiments in the future and would potentially benefit from participation in this study in terms of pain control.
  • 1. Patients receiving any regional/neuraxial anesthetic techniques or ketamine infusion before randomization
  • 2. Adults with diminished decision-making capacity
  • 3. Adults of limited English proficiency/non-English speakers
  • 4. Prisoners
  • 5. Pregnant or breastfeeding women
  • 6. Patient admission weight greater than 120 kg
  • 7. Patients with any of the following medical history:
  • 1. Active delirium (as defined by Confusion Assessment Method)
  • 2. Dementia
  • 3. Psychosis
  • 4. Glaucoma
  • 5. Heart block (except with patients with a functioning artificial pacemaker)
  • 6. Congestive heart failure (ejection fraction \<20% recorded in last year)
  • 7. Adams-Stokes syndrome
  • 8. Wolff-Parkinson-White Syndrome
  • 8. Patient is unable to communicate with staff for pain assessments at time of enrollment
  • 9. Most recent documented Glasgow Coma Score \<15 at the time of study enrollment
  • 10. Severe bradycardia (heart rate \<50 bpm based on last vital sign recorded at time of study enrollment)
  • 11. Sustained hypertension (systolic blood pressure \>180 mm Hg or diastolic blood pressure \>100 mm Hg for at least 3 sets of vital signs in a row prior to study enrollment)
  • 12. Any seizure suspected or identified during hospital admission
  • 13. Patient with active acute coronary syndrome obtained from admission problem list
  • 14. Patients with known hepatic disease or acute liver failure
  • 15. Patients with a history of end-stage renal disease or admission creatinine clearance (CrCl) ≤30 ml/min
  • 16. Use of antiarrhythmic medication therapy prior or during admission
  • 17. Patients with a known allergy/sensitivity to lidocaine or ketamine, amide anesthetics, or components of the solution
  • 18. Patients who, in the investigator's opinion, should not be included in this study.

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Brittany Hoyte,

Study Record Dates

2026-01