Multimodal Brain Imaging of the Neural Effects of Methylphenidate in Patients With ADHD

Description

The investigators' goal is to develop neuroimaging biomarkers to predict response to treatment with methylphenidate, which then can be used in the development of novel pharmacological treatments for attention-deficit/hyperactivity disorder (ADHD). The overall objective of this study is to measure the changes in task-related neural activity related to symptoms of ADHD (measured by functional MRI) and brain glutamate levels (measured by magnetic resonance spectroscopy, MRS) after treatment with methylphenidate (MPH). This will be a double-blind crossover of methylphenidate and placebo in adults with ADHD. Participants will complete neuropsychological testing along with fMRI and MRS scans after a single dose of each treatment.

Conditions

ADHD - Combined Type

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Study Overview

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Study Details

Study overview

The investigators' goal is to develop neuroimaging biomarkers to predict response to treatment with methylphenidate, which then can be used in the development of novel pharmacological treatments for attention-deficit/hyperactivity disorder (ADHD). The overall objective of this study is to measure the changes in task-related neural activity related to symptoms of ADHD (measured by functional MRI) and brain glutamate levels (measured by magnetic resonance spectroscopy, MRS) after treatment with methylphenidate (MPH). This will be a double-blind crossover of methylphenidate and placebo in adults with ADHD. Participants will complete neuropsychological testing along with fMRI and MRS scans after a single dose of each treatment.

Multimodal Brain Imaging of the Neural Effects of Methylphenidate in Patients With ADHD

Multimodal Brain Imaging of the Neural Effects of Methylphenidate in Patients With ADHD

Condition
ADHD - Combined Type
Intervention / Treatment

-

Contacts and Locations

Baltimore

Johns Hopkins School of Medicine, Baltimore, Maryland, United States, 21205

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * right handed
  • * pregnant or breast feeding
  • * past or current neurological disorder
  • * non-ADHD cause of cognitive impairment
  • * uncontrolled medical disorder
  • * head trauma with loss of consciousness in the last year or any evidence of functional impairment due to and persisting after head trauma
  • * having an adverse reaction to methylphenidate, or other stimulant medication
  • * having a contraindication to MRI
  • * current smoking

Ages Eligible for Study

6 Years to 40 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Johns Hopkins University,

Kristin L Bigos, PhD, PRINCIPAL_INVESTIGATOR, Johns Hopkins School of Medicine

Study Record Dates

2025-05-01