Preoperative Melatonin to Decrease Analgesia Usage After Third Molar Surgery

Description

The purpose of the study is to assess if melatonin given for three nights before wisdom tooth surgery decreases post-operative pain and pain medication consumption. Patients will receive either melatonin or a placebo for three nights prior to surgery and we will measure pre-operative anxiety, preoperative sleep quality, post op pain medication consumption, post op pain scores, and blood values.

Conditions

Pain, Postoperative, Narcotic Use

Study Overview

Study Details

Study overview

The purpose of the study is to assess if melatonin given for three nights before wisdom tooth surgery decreases post-operative pain and pain medication consumption. Patients will receive either melatonin or a placebo for three nights prior to surgery and we will measure pre-operative anxiety, preoperative sleep quality, post op pain medication consumption, post op pain scores, and blood values.

Preoperative Melatonin to Decrease Analgesia Usage After Third Molar Surgery

Preoperative Melatonin to Decrease Analgesia Usage After Third Molar Surgery

Condition
Pain, Postoperative
Intervention / Treatment

-

Contacts and Locations

Bronx

Montefiore Medical Center Department of Dentistry, Bronx, New York, United States, 10467

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Subject must have 3-4 partial or full bony impacted third molars requiring surgical extraction under IV sedation
  • * Ages 18-35
  • * ASA Class I or II
  • * English or Spanish speaking patients
  • * Capacity to sign informed consent
  • * Allergies to melatonin, opioids, or other OTC pain medications
  • * Anyone currently taking melatonin for any reason
  • * Cases under local anesthesia
  • * ASA class III or higher
  • * Sleep disorder (insomnia/narcolepsy)
  • * Current or past history of substance abuse
  • * Chronic pain
  • * Language/communication barrier
  • * Psychiatric disease/ Mental impairment
  • * Current or past use of psychotropic drugs
  • * Pregnancy
  • * Renal or hepatic impairment
  • * BMI \>35

Ages Eligible for Study

18 Years to 35 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Montefiore Medical Center,

Jason Baker, DMD, PRINCIPAL_INVESTIGATOR, Montefiore Medical Center

Study Record Dates

2025-12