RECRUITING

Regional Phenotyping of CF and Non-CF Bronchiectasis

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The Investigators propose to study pediatric subjects who are diagnosed with cystic fibrosis (CF) and patients with non-CF bronchiectasis, with the goal of developing markers of CF lung disease severity, progression, and therapy response. The Investigator's central hypothesis is that image-based markers can forecast pathophysiology prior to spirometric changes.

Official Title

Regional Phenotyping of Cystic Fibrosis Lung Disease and Non-CF Bronchiectasis

Quick Facts

Study Start:2021-02-08
Study Completion:2027-03
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT04793867

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:5 Years to 100 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:CHILD, ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * CF Patients: Diagnosis of CF based on sweat chloride \>60 mMol/l
  2. * Presence of two disease causing CFTR mutations, or end organ manifestations of disease.
  3. * Age minimum 5 years.
  4. * Care provided by the CCHMC CF Care Center or other regional CF Care Centers if required to achieve recruitment goals.
  1. * Patients meeting standard MRI exclusions criteria (non-MRI-compatible metal implants, claustrophobia, etc.)
  2. * Pregnancy or lactation.
  3. * Subjects 5 years of age and older with no known history of cardiopulmonary disease.
  4. * Patients meeting standard MRI exclusions criteria (non-MRI-compatible metal implants, claustrophobia, etc.)
  5. * Pregnancy or lactation.

Contacts and Locations

Study Contact

Miranda E Ruark, MS
CONTACT
513-636-8715
Miranda.Ruark@cchmc.org
Carrie Stevens, BS
CONTACT
513-636-9973
carrie.stevens@cchmc.org

Principal Investigator

Zackary I Cleveland, PhD
PRINCIPAL_INVESTIGATOR
CCHMC

Study Locations (Sites)

Miranda E Ruark
Cincinnati, Ohio, 45229
United States

Collaborators and Investigators

Sponsor: Children's Hospital Medical Center, Cincinnati

  • Zackary I Cleveland, PhD, PRINCIPAL_INVESTIGATOR, CCHMC

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-02-08
Study Completion Date2027-03

Study Record Updates

Study Start Date2021-02-08
Study Completion Date2027-03

Terms related to this study

Keywords Provided by Researchers

  • Cystic Fibrosis
  • hyperpolarized xenon
  • LCI
  • Non-CF Bronchiectasis

Additional Relevant MeSH Terms

  • Cystic Fibrosis
  • Non-CF Bronchiectasis