Regional Phenotyping of CF and Non-CF Bronchiectasis

Description

The Investigators propose to study pediatric subjects who are diagnosed with cystic fibrosis (CF) and patients with non-CF bronchiectasis, with the goal of developing markers of CF lung disease severity, progression, and therapy response. The Investigator's central hypothesis is that image-based markers can forecast pathophysiology prior to spirometric changes.

Conditions

Cystic Fibrosis, Non-CF Bronchiectasis

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Study Overview

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Study Details

Study overview

The Investigators propose to study pediatric subjects who are diagnosed with cystic fibrosis (CF) and patients with non-CF bronchiectasis, with the goal of developing markers of CF lung disease severity, progression, and therapy response. The Investigator's central hypothesis is that image-based markers can forecast pathophysiology prior to spirometric changes.

Regional Phenotyping of Cystic Fibrosis Lung Disease and Non-CF Bronchiectasis

Regional Phenotyping of CF and Non-CF Bronchiectasis

Condition
Cystic Fibrosis
Intervention / Treatment

-

Contacts and Locations

Cincinnati

Miranda E Ruark, Cincinnati, Ohio, United States, 45229

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * CF Patients: Diagnosis of CF based on sweat chloride \>60 mMol/l
  • * Presence of two disease causing CFTR mutations, or end organ manifestations of disease.
  • * Age minimum 5 years.
  • * Care provided by the CCHMC CF Care Center or other regional CF Care Centers if required to achieve recruitment goals.
  • * Patients meeting standard MRI exclusions criteria (non-MRI-compatible metal implants, claustrophobia, etc.)
  • * Pregnancy or lactation.
  • * Subjects 5 years of age and older with no known history of cardiopulmonary disease.
  • * Patients meeting standard MRI exclusions criteria (non-MRI-compatible metal implants, claustrophobia, etc.)
  • * Pregnancy or lactation.

Ages Eligible for Study

5 Years to 100 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Children's Hospital Medical Center, Cincinnati,

Zackary I Cleveland, PhD, PRINCIPAL_INVESTIGATOR, CCHMC

Study Record Dates

2027-03