ACTIVE_NOT_RECRUITING

SARS-Cov-2 (COVID-19) Nasal Pharyngeal and Oral Pharyngeal Wash (SNOW) Trial

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Conditions

Covid19SARS-CoV InfectionCovid 19SARS-CoV-2Viral LoadNasal RinseOral Rinse

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Adults (aged 18-65 years) recently diagnosed with SARS-CoV-2 infection who use a 4-day combined intervention of nasal washes with 1% baby shampoo solution and oral gargles with Listerine Antiseptic® will have a reduced SARS-CoV-2 viral load compared to those using nasal and oral washes with normal saline. This combined intervention should be acceptable, tolerable and safe in this population. To test this, investigators are conducting a trial comparing the efficacy of a number of washes in reducing the oral and nasal SARS-CoV-2 viral load among adults.

Official Title

SARS-Cov-2 (COVID-19) Nasal Pharyngeal and Oral Pharyngeal Wash (SNOW) Trial

Quick Facts

Study Start:2021-10-01
Study Completion:2026-05-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:ACTIVE_NOT_RECRUITING

Study ID

NCT04802408

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 65 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. 1. A first-time positive test for SARS-CoV-2 infection within 5 days of enrollment
  2. 2. Adults who are ≥18 -65 years of age
  3. 3. Currently in isolation
  4. 4. Symptomatic or asymptomatic from SARS-CoV-2
  1. 1. History of nasal or sinus surgery
  2. 2. Non-English speaking
  3. 3. Lack of electronic device (computer, mobile phone etc.) on which to access an app for study data collection.
  4. 4. Adults that need inpatient care for COVID-19 or any of its complications.
  5. 5. Adults that give a history of being unable to tolerate gargles or nasal washes.
  6. 6. Adults who do not give informed consent for study participation.
  7. 7. History of a Covid vaccine booster
  8. 8. A history of use of nasal or oral washes after SARS-CoV-2 test sample collection.
  9. 9. Prisoners
  10. 10. Adults that give history of current pregnancy (NO KNOWN CONTRAINDICATION TO PREGNANCY)
  11. 11. History of monoclonal antibody treatment
  12. 12. History of or current molnupiravir treatment

Contacts and Locations

Principal Investigator

Rena Kass, MD
PRINCIPAL_INVESTIGATOR
Penn State College of Medicine

Study Locations (Sites)

Penn State Health Milton S. Hershey Medical Center
Hershey, Pennsylvania, 17033
United States
Penn State
State College, Pennsylvania, 16801
United States

Collaborators and Investigators

Sponsor: Milton S. Hershey Medical Center

  • Rena Kass, MD, PRINCIPAL_INVESTIGATOR, Penn State College of Medicine

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2021-10-01
Study Completion Date2026-05-30

Study Record Updates

Study Start Date2021-10-01
Study Completion Date2026-05-30

Terms related to this study

Keywords Provided by Researchers

  • Covid 19
  • SARS-CoV-2
  • Viral Load
  • Nasal Rinse
  • Oral Rinse

Additional Relevant MeSH Terms

  • Covid19
  • SARS-CoV Infection