SARS-Cov-2 (COVID-19) Nasal Pharyngeal and Oral Pharyngeal Wash (SNOW) Trial

Description

Adults (aged 18-65 years) recently diagnosed with SARS-CoV-2 infection who use a 4-day combined intervention of nasal washes with 1% baby shampoo solution and oral gargles with Listerine Antiseptic® will have a reduced SARS-CoV-2 viral load compared to those using nasal and oral washes with normal saline. This combined intervention should be acceptable, tolerable and safe in this population. To test this, investigators are conducting a trial comparing the efficacy of a number of washes in reducing the oral and nasal SARS-CoV-2 viral load among adults.

Conditions

Covid19, SARS-CoV Infection

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Study Overview

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Study Details

Study overview

Adults (aged 18-65 years) recently diagnosed with SARS-CoV-2 infection who use a 4-day combined intervention of nasal washes with 1% baby shampoo solution and oral gargles with Listerine Antiseptic® will have a reduced SARS-CoV-2 viral load compared to those using nasal and oral washes with normal saline. This combined intervention should be acceptable, tolerable and safe in this population. To test this, investigators are conducting a trial comparing the efficacy of a number of washes in reducing the oral and nasal SARS-CoV-2 viral load among adults.

SARS-Cov-2 (COVID-19) Nasal Pharyngeal and Oral Pharyngeal Wash (SNOW) Trial

SARS-Cov-2 (COVID-19) Nasal Pharyngeal and Oral Pharyngeal Wash (SNOW) Trial

Condition
Covid19
Intervention / Treatment

-

Contacts and Locations

Hershey

Penn State Health Milton S. Hershey Medical Center, Hershey, Pennsylvania, United States, 17033

State College

Penn State, State College, Pennsylvania, United States, 16801

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. A first-time positive test for SARS-CoV-2 infection within 5 days of enrollment
  • 2. Adults who are ≥18 -65 years of age
  • 3. Currently in isolation
  • 4. Symptomatic or asymptomatic from SARS-CoV-2
  • 1. History of nasal or sinus surgery
  • 2. Non-English speaking
  • 3. Lack of electronic device (computer, mobile phone etc.) on which to access an app for study data collection.
  • 4. Adults that need inpatient care for COVID-19 or any of its complications.
  • 5. Adults that give a history of being unable to tolerate gargles or nasal washes.
  • 6. Adults who do not give informed consent for study participation.
  • 7. History of a Covid vaccine booster
  • 8. A history of use of nasal or oral washes after SARS-CoV-2 test sample collection.
  • 9. Prisoners
  • 10. Adults that give history of current pregnancy (NO KNOWN CONTRAINDICATION TO PREGNANCY)
  • 11. History of monoclonal antibody treatment
  • 12. History of or current molnupiravir treatment

Ages Eligible for Study

18 Years to 65 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Milton S. Hershey Medical Center,

Rena Kass, MD, PRINCIPAL_INVESTIGATOR, Penn State College of Medicine

Study Record Dates

2026-05-30