Modeling the Effects of Chronic Marijuana Use on Neuroinflammation and HIV-related Neuronal Injury

Description

This study applies a hypothesis-driven approach to examine the effects of chronic marijuana use on HIV-associated inflammation and its subsequent impacts on central nervous system function, with the goal of identifying the mechanisms through which cannabinoids modulate neurological disorders and other comorbidities in persons with HIV.

Conditions

Cannabis, HIV, Inflammation, Cognition, Neuroimaging

Study Overview

Study Details

Study overview

This study applies a hypothesis-driven approach to examine the effects of chronic marijuana use on HIV-associated inflammation and its subsequent impacts on central nervous system function, with the goal of identifying the mechanisms through which cannabinoids modulate neurological disorders and other comorbidities in persons with HIV.

Modeling the Effects of Chronic Marijuana Use on Neuroinflammation and HIV-related Neuronal Injury

Modeling the Effects of Chronic Marijuana Use on Neuroinflammation and HIV-related Neuronal Injury

Condition
Cannabis
Intervention / Treatment

-

Contacts and Locations

Winston-Salem

Biotech Place, Winston-Salem, North Carolina, United States, 27101

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * verified HIV status
  • * Current marijuana use (MJ+ groups only)
  • * No current marijuana use (MJ- groups only)
  • * current engagement in HIV care (HIV+ participants only)
  • * receipt of cART as first-line of treatment (HIV+ participants only)
  • * stable cART regimen (HIV+ participants only)
  • * undetectable HIV RNA viral load for \>1 year (HIV+ participants only)
  • * Lifetime abuse for any illicit drug other than marijuana
  • * \<9th grade education; illiteracy or lack of fluency in English
  • * history of moderate or severe head trauma
  • * unstable or serious neurological disorders
  • * severe mental illness
  • * systemic autoimmune diseases
  • * immunotherapy
  • * MRI contraindications

Ages Eligible for Study

25 Years to 59 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Wake Forest University Health Sciences,

Christina S Meade, PhD, PRINCIPAL_INVESTIGATOR, Duke University

Study Record Dates

2025-05-31