Exercise Effects on Adipose Tissue Structure and Function

Description

Participants will be randomized into one of two different experimental groups: 1) Exercise group and 2) No exercise (control group). Subject participation in the study will involve a series of metabolic tests before and after participants undergo a 10% weight loss program (with or without exercise training depending on group randomization). After completing this weight loss portion of the study, participants will then be required to adhere to a high calorie diet program to regain half of the weight the participant lost - followed by the same series of metabolic tests.

Conditions

Obesity, Metabolic Syndrome, Metabolic Disease, Insulin Resistance, Weight Loss, Weight Gain

Study Overview

Study Details

Study overview

Participants will be randomized into one of two different experimental groups: 1) Exercise group and 2) No exercise (control group). Subject participation in the study will involve a series of metabolic tests before and after participants undergo a 10% weight loss program (with or without exercise training depending on group randomization). After completing this weight loss portion of the study, participants will then be required to adhere to a high calorie diet program to regain half of the weight the participant lost - followed by the same series of metabolic tests.

Exercise Effects on Adipose Tissue Structure and Function

Exercise Effects on Adipose Tissue Structure and Function

Condition
Obesity
Intervention / Treatment

-

Contacts and Locations

Ann Arbor

University of Michigan, Ann Arbor, Michigan, United States, 48109

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age: 18-40
  • * Body Mass Index: 27-45 kg/m2
  • * No regularly planned exercise/physical activity for at least 6 months
  • * Women must have regularly occurring menses and must be premenopausal
  • * Evidence/history of cardiovascular or metabolic disease
  • * Medications known to affect lipid or glucose metabolism, or inflammation
  • * Weight instability ≥ ± 6 pounds in the last 3 months
  • * Tobacco or e-cigarette users
  • * Women must not be pregnant or actively lactating

Ages Eligible for Study

18 Years to 40 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Michigan,

Jeffrey F Horowitz, PhD, PRINCIPAL_INVESTIGATOR, University of Michigan, School of Kinesiology

Study Record Dates

2030-03-01