Breast Cancer, Reasoning, and Activity Intervention

Description

This phase II trial tests whether an exercise intervention works to improve cognitive function in breast cancer survivors. Many breast cancer survivors report cancer-related cognitive impairment, which this has recently become a priority in clinical research due to its dramatic impact on daily functioning, quality of life, and long-term health. Aerobic exercise has the potential to improve cognitive function and brain health in older adults and is recommended as a safe, tolerable, and accessible complementary therapy for breast cancer survivors. This study aims to understand the effects of physical activity compared with health education on memory, attention, and brain health in women with breast cancer. Study findings may help researchers design more programs that can improve memory, attention, and brain health in other women with breast cancer.

Conditions

Breast Cancer, Breast Neoplasms, Anatomic Stage I Breast Cancer AJCC V8, Anatomic Stage II Breast Cancer AJCC V8, Anatomic Stage IIIA Breast Cancer AJCC V8, Cancer-related Cognitive Dysfunction

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Study Overview

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Study Details

Study overview

This phase II trial tests whether an exercise intervention works to improve cognitive function in breast cancer survivors. Many breast cancer survivors report cancer-related cognitive impairment, which this has recently become a priority in clinical research due to its dramatic impact on daily functioning, quality of life, and long-term health. Aerobic exercise has the potential to improve cognitive function and brain health in older adults and is recommended as a safe, tolerable, and accessible complementary therapy for breast cancer survivors. This study aims to understand the effects of physical activity compared with health education on memory, attention, and brain health in women with breast cancer. Study findings may help researchers design more programs that can improve memory, attention, and brain health in other women with breast cancer.

Enhancing Cognitive Function in Breast Cancer Survivors Through Community-based Exercise Training

Breast Cancer, Reasoning, and Activity Intervention

Condition
Breast Cancer
Intervention / Treatment

-

Contacts and Locations

Scottsdale

Mayo Clinic in Arizona, Scottsdale, Arizona, United States, 85259

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * PRE-REGISTRATION: Individual who was pre- or peri-menopausal at the time of diagnosis with breast cancer
  • * PRE-REGISTRATION: Stage 0 breast cancer diagnosis OR metastatic disease
  • * PRE-REGISTRATION: Currently receiving or \< 3 months since receiving chemotherapy or radiation therapy for cancer, or greater than 24 months post primary treatment
  • * PRE-REGISTRATION: Planned surgery during the intervention period
  • * PRE-REGISTRATION: Second cancer diagnosis (excluding non-invasive skin cancers or carcinoma-in-situ for any cancer)
  • * PRE-REGISTRATION: Unable to travel regularly to the study locations for intervention sessions and data collection
  • * PRE-REGISTRATION: Unwilling to return to enrolling institution for follow-up
  • * PRE-REGISTRATION: Self-reported inability to walk without assistance or devices
  • * REGISTRATION: History of stroke, transient ischemic attack, other neurological disorders, or brain surgery involving tissue removal as confirmed via clinical determination
  • * REGISTRATION: Clinically significant TICS-M score (\< 21) during baseline procedures
  • * REGISTRATION: Not able to provide physician re-clearance for exercise if required based upon clinically significant baseline exercise test (as determined by ECG and blood pressure monitoring)
  • * REGISTRATION: Contraindications to functional magnetic resonance imaging (fMRI) in accordance with the Mayo Clinic Department of Radiology safety protocols
  • * REGISTRATION: Clinically significant MRI scan as determined by physician review in which the following is advised via radiologist overread: remarkable/abnormal limited diagnostic brain image with recommended medical follow-up
  • * REGISTRATION: Enrolled in another physical activity program
  • * REGISTRATION: Unable to walk without assistance or devices
  • * REGISTRATION: Unwilling to complete study requirements
  • * REGISTRATION: Unwilling to be randomized to the exercise group or health education group
  • * REGISTRATION: Unable or unwilling to continuously wear and regularly sync/charge an activity tracker during the study period
  • * REGISTRATION: Unable to travel regularly to the study locations for intervention sessions and data collection
  • * REGISTRATION: Unwilling to return to enrolling institution for follow-up

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

No

Collaborators and Investigators

Mayo Clinic,

Diane K. Ehlers, Ph.D., PRINCIPAL_INVESTIGATOR, Mayo Clinic

Study Record Dates

2027-07-31