Reversing Glucose and Lipid-mediated Vascular Dysfunction

Description

The purpose of our study is to understand the extent to which the blood vessels are affected by glucose and fat (lipids) in lean healthy adults and if these changes in the blood vessels contribute to the development of high blood pressure.

Conditions

Blood Pressure, Hypertension

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Study Overview

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Study Details

Study overview

The purpose of our study is to understand the extent to which the blood vessels are affected by glucose and fat (lipids) in lean healthy adults and if these changes in the blood vessels contribute to the development of high blood pressure.

Reversing Glucose and Lipid-mediated Vascular Dysfunction (REGAL)

Reversing Glucose and Lipid-mediated Vascular Dysfunction

Condition
Blood Pressure
Intervention / Treatment

-

Contacts and Locations

Kansas City

University of Kansas Medical Center, Kansas City, Kansas, United States, 66103

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Lean: BMI \< 25 kg/m
  • * Normal insulin sensitivity: (calculation based on fasting glucose and insulin concentrations in blood)
  • * Middle-aged: 18-79 years
  • * Blood pressure: \< 140 (systolic) and \< 90 mmHg (diastolic
  • * Weight stable (+/- 5 lbs) for the previous 3 months
  • * Participants must be willing and able to discontinue taking any vitamin C or E supplements or omega-3 fatty acids beginning 2 weeks prior.
  • * Able and willing to provide written informed consent
  • * Diabetes mellitus Type I or Type II: fasting glucose \< 126 mg/dL and/or HbA1c \< 6.5%
  • * Current smoker or History of smoking in the past 3 months.
  • * Hyperlipidemia: Fasting triglycerides \< 250 mg/dL
  • * Hypertension: \>130/80 mmHg
  • * History of heart disease (e.g., myocardial infarction, stent, heart attack, stroke, heart failure, valvular heart disease, cardiomyopathy)
  • * History of vascular disease (e.g., bypass, stroke)

Ages Eligible for Study

18 Years to 79 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Kansas Medical Center,

Seth W. W Holwerda, PhD, PRINCIPAL_INVESTIGATOR, University of Kansas Medical Center

Study Record Dates

2025-01-01